TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TCF21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCF21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCF21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:133,887,777–133,888,013 | 1.1 kb | Proximal (<10kb) | 68 | |
| chr6:133,888,652–133,890,259 | at TSS | At TSS | 323 | |
| chr6:133,890,721–133,890,851 | 1.6 kb | Proximal (<10kb) | 28 | |
| chr6:133,891,167–133,891,948 | 2.1 kb | Proximal (<10kb) | 305 | |
| chr6:133,892,783–133,893,405 | 3.7 kb | Proximal (<10kb) | 172 | |
| chr6:133,895,588–133,896,547 | 6.5 kb | Proximal (<10kb) | 186 |
Genomic view of the TCF21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.