Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in cellular response to retinoic acid; regulation of transcription by RNA polymerase II; and spermatogenesis. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF35. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF35 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF35, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:44,477,346–44,478,014 | 171.1 kb | Distal (>10kb) Multiome | 561 | |
| chr3:44,510,368–44,511,080 | 138.0 kb | Distal (>10kb) Multiome | 607 | |
| chr3:44,554,965–44,555,488 | 93.6 kb | Distal (>10kb) Multiome | 434 | |
| chr3:44,584,465–44,585,362 | 63.9 kb | Distal (>10kb) Multiome | 388 | |
| chr3:44,624,770–44,625,563 | 23.7 kb | Distal (>10kb) Multiome | 686 | |
| chr3:44,648,515–44,649,232 | 17 bp | At TSS Multiome | 554 | |
| chr3:44,729,240–44,729,901 | 80.8 kb | Distal (>10kb) Multiome | 780 | |
| chr3:44,761,326–44,762,300 | 113.0 kb | Distal (>10kb) Multiome | 966 | |
| chr3:44,861,375–44,862,600 | 213.1 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the ZNF35 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.