The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for NUMB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUMB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUMB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:73,168,802–73,169,764 | 289.3 kb | Distal (>10kb) Multiome | 44 | |
| chr14:73,235,444–73,236,071 | 222.8 kb | Distal (>10kb) Multiome | 85 | |
| chr14:73,237,315–73,238,355 | 220.7 kb | Distal (>10kb) Multiome | 296 | |
| chr14:73,457,486–73,459,145 | 153 bp | At TSS Multiome | 720 | |
| chr14:73,490,604–73,491,982 | 32.5 kb | Distal (>10kb) Multiome | 866 | |
| chr14:73,569,145–73,570,199 | 110.8 kb | Distal (>10kb) Multiome | 680 | |
| chr14:73,591,810–73,592,493 | 133.6 kb | Distal (>10kb) Multiome | 259 | |
| chr14:73,612,266–73,613,237 | 154.1 kb | Distal (>10kb) Multiome | 521 | |
| chr14:73,633,521–73,634,788 | 175.1 kb | Distal (>10kb) Multiome | 541 | |
| chr14:73,644,535–73,645,291 | 186.4 kb | Distal (>10kb) Multiome | 667 | |
| chr14:73,713,545–73,714,769 | 255.8 kb | Distal (>10kb) Multiome | 759 | |
| chr14:73,718,770–73,719,334 | 260.6 kb | Distal (>10kb) Multiome | 138 |
Genomic view of the NUMB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.