The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for ZFYVE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFYVE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFYVE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:72,893,140–72,894,397 | 132.9 kb | Distal (>10kb) Multiome | 484 | |
| chr14:72,925,756–72,927,231 | 100.8 kb | Distal (>10kb) Multiome | 799 | |
| chr14:73,026,575–73,027,593 | 63 bp | At TSS Multiome | 727 | |
| chr14:73,058,025–73,059,316 | 31.4 kb | Distal (>10kb) Multiome | 949 | |
| chr14:73,125,023–73,126,032 | 98.3 kb | Distal (>10kb) Multiome | 131 | |
| chr14:73,136,098–73,137,113 | 109.4 kb | Distal (>10kb) Multiome | 737 | |
| chr14:73,168,802–73,169,764 | 142.1 kb | Distal (>10kb) Multiome | 44 | |
| chr14:73,235,444–73,236,071 | 208.6 kb | Distal (>10kb) Multiome | 85 | |
| chr14:73,237,315–73,238,355 | 210.8 kb | Distal (>10kb) Multiome | 296 |
Genomic view of the ZFYVE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.