chr22:40,684,688–40,685,220

chr22 : 40,684,688 – 40,685,220

532 bp 101 TFs 7 linked genes

This 532 bp open chromatin element is linked to 7 target genes and is bound by 101 transcription factors.

Linked Genes

7 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000289292		at TSS	At TSS	Proximity
MCHR1		5.2 kb	Proximal	Proximity
MRTFA		48.2 kb	Distal	Multiome
SLC25A17		134.4 kb	Distal	Multiome
ST13		171.7 kb	Distal	Multiome
XPNPEP3		172.2 kb	Distal	Multiome
RBX1		266.5 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

101 transcription factors

ChIP prostate_fetal-fibroblast GSE90772.AR.prostate_fetal-fibroblast 152 bp overlap

ASCL1 1 dataset

ChIP NCI-H82 GSE69394.ASCL1.NCI-H82 169 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 532 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 532 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 134 bp overlap

Ahr::Arnt 1 dataset

Motif DE_12h DE_12h-AhrArnt_MA0006.2 5 bp overlap

BCL11B 1 dataset

ChIP thymus_CD34neg GSE84677.BCL11B.thymus_CD34neg 111 bp overlap

BCOR 3 datasets

ChIP WA01 GSE104690.BCOR.WA01 308 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 499 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 532 bp overlap

BMPR1A 1 dataset

ChIP HUVEC-C GSE60156.BMPR1A.HUVEC-C 239 bp overlap

BRD1 2 datasets

ChIP HUES-64 GSE104059.BRD1.HUES-64 367 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 111 bp overlap

BRD4 12 datasets

ChIP CD4_JG1 GSE33281.BRD4.CD4_JG1 354 bp overlap

ChIP CLL_patient2 GSE109411.BRD4.CLL_patient2 60 bp overlap

ChIP CLL_patient3 GSE109411.BRD4.CLL_patient3 226 bp overlap

ChIP KOPT-K1 GSE54379.BRD4.KOPT-K1 532 bp overlap

ChIP KOPT-K1_E GSE54379.BRD4.KOPT-K1_E 532 bp overlap

ChIP MCF-7_ARID1A-KO GSE123284.BRD4.MCF-7_ARID1A-KO 438 bp overlap

ChIP hESC GSE33281.BRD4.hESC 72 bp overlap

ChIP hESC GSE33281.BRD4.hESC 90 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 359 bp overlap

ChIP retina_AB1-FW20 GSE86981.BRD4.retina_AB1-FW20 314 bp overlap

ChIP retina_AB1-FW23 GSE86981.BRD4.retina_AB1-FW23 465 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 326 bp overlap

CHD4 3 datasets

ChIP 501-mel GSE134848.CHD4.501-mel 157 bp overlap

ChIP RH5 GSE155861.CHD4.RH5 532 bp overlap

ChIP SCMC GSE155861.CHD4.SCMC 375 bp overlap

CREB1 3 datasets

ChIP GM23338 ENCSR214ZAV.CREB1.GM23338 146 bp overlap

ChIP H1 ENCFF955PMP 288 bp overlap

ChIP WA01 ENCSR000BSN.CREB1.WA01 137 bp overlap

ChIP U2OS GSE44236.CRY1.U2OS 205 bp overlap

CTBP2 1 dataset

ChIP WA01 ENCSR000EUO.CTBP2.WA01 214 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 262 bp overlap

ChIP ProEs GSE59087.EED.ProEs 151 bp overlap

Motif DE_12h DE_12h-EGR1_MA0162.5 10 bp overlap

ChIP HEK293 ENCFF336LFH 394 bp overlap

Motif DE_12h DE_12h-EGR3_MA0732.2 11 bp overlap

Motif DE_12h DE_12h-EGR4_MA0733.2 11 bp overlap

ETS1 5 datasets

ChIP CTV-1_DSG GSE128835.ETS1.CTV-1_DSG 532 bp overlap

ChIP CTV-1_DSG_SPI1-mut GSE128835.ETS1.CTV-1_DSG_SPI1-mut 425 bp overlap

ChIP THP-6_shCtrl GSE138516.ETS1.THP-6_shCtrl 254 bp overlap

ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 156 bp overlap

ChIP hESC ENCSR534VHI.ETS1.hESC 248 bp overlap

ETV6 2 datasets

ChIP Reh_pCCL-ETV6-HA GSE102785.ETV6.Reh_pCCL-ETV6-HA 215 bp overlap

ChIP WTC11 ENCFF812SCD 325 bp overlap

ChIP RH30_DMSO GSE85169.EZH2.RH30_DMSO 531 bp overlap

FLI1 2 datasets

ChIP CTV-1_DSG GSE128835.FLI1.CTV-1_DSG 195 bp overlap

ChIP CTV-1_DSG_SPI1-mut GSE128835.FLI1.CTV-1_DSG_SPI1-mut 251 bp overlap

FOXA1 1 dataset

ChIP breast_tumor_Male_13 GSE104399.FOXA1.breast_tumor_Male_13 169 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 300 bp overlap

ChIP DE DE-FOXA2-2 310 bp overlap

FOXK1 1 dataset

ChIP WTC11 ENCFF875IGU 346 bp overlap

FOXO6 1 dataset

Motif DE_12h DE_12h-FOXO6_MA0849.1 7 bp overlap

FOXP4 2 datasets

ChIP WTC11 ENCFF708TAF 301 bp overlap

ChIP WTC11 ENCFF708TAF 377 bp overlap

GATA6 1 dataset

ChIP PATU8988 GSE47535.GATA6.PATU8988 112 bp overlap

GTF3C2 1 dataset

ChIP H9 GSE94418.GTF3C2.H9 257 bp overlap

HDAC2 3 datasets

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 144 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 146 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 401 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 532 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 321 bp overlap

KDM1A 1 dataset

ChIP H1 ENCFF696SGD 454 bp overlap

KDM4A 1 dataset

ChIP hiPSC_IA12 GSE106870.KDM4A.hiPSC_IA12 168 bp overlap

ChIP HEK293 ENCSR859BMR.KLF1.HEK293 356 bp overlap

KLF11 2 datasets

Motif DE_12h DE_12h-KLF11_MA1512.2 10 bp overlap

Motif DE_12h DE_12h-KLF11_MA1512.2 10 bp overlap

KLF16 1 dataset

Motif DE_12h DE_12h-KLF16_MA0741.1 11 bp overlap

KLF17 1 dataset

Motif DE_12h DE_12h-KLF17_MA1514.2 14 bp overlap

KLF4 2 datasets

ChIP WA09 GSE105028.KLF4.WA09 205 bp overlap

ChIP hiPSC GSE56567.KLF4.hiPSC 363 bp overlap

Motif DE_12h DE_12h-KLF6_MA1517.2 9 bp overlap

Motif DE_12h DE_12h-KLF9_MA1107.3 11 bp overlap

KMT2A 1 dataset

ChIP CCRF-CEM GSE83671.KMT2A.CCRF-CEM 255 bp overlap

ChIP CD4_TH2 GSE72266.MAF.CD4_TH2 361 bp overlap

ChIP THP-1_macrophage_PMA GSE96800.MAF1.THP-1_macrophage_PMA 163 bp overlap

ChIP H1 ENCFF914VQY 357 bp overlap

ChIP H1 ENCFF914VQY 132 bp overlap

ChIP WTC11 ENCFF223QFY 348 bp overlap

ChIP WTC11 ENCFF223QFY 139 bp overlap

ChIP melanocyte GSE115845.MAX.melanocyte 130 bp overlap

MLLT1 1 dataset

ChIP K-562 ENCSR107GRP.MLLT1.K-562 194 bp overlap

MORC2 1 dataset

ChIP H9 GSE95374.MORC2.H9 147 bp overlap

ChIP MOLT-3 GSE59657.MYB.MOLT-3 312 bp overlap

MYBL2 2 datasets

ChIP WTC11 ENCFF166TKT 358 bp overlap

ChIP WTC11 ENCFF166TKT 419 bp overlap

MYOD1 4 datasets

ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 517 bp overlap

ChIP RH4 GSE83726.MYOD1.RH4 180 bp overlap

ChIP SMS-CTR GSE137168.MYOD1.SMS-CTR 176 bp overlap

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 259 bp overlap

NANOG 5 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 523 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 209 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 139 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 383 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 332 bp overlap

NFE2L1 1 dataset

ChIP WTC11 ENCFF644BPU 369 bp overlap

NFKB1 1 dataset

ChIP HEK293T_2KR GSE129618.NFKB1.HEK293T_2KR 299 bp overlap

NIPBL 2 datasets

ChIP hESC_WNT3A GSE64758.NIPBL.hESC_WNT3A 201 bp overlap

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 197 bp overlap

NOTCH1 1 dataset

ChIP HPBALL GSE39263.NOTCH1.HPBALL 497 bp overlap

NR3C1 1 dataset

ChIP U2OS_SHHIC5 GSE65847.NR3C1.U2OS_SHHIC5 234 bp overlap

PCBP2 2 datasets

ChIP Hep-G2 ENCSR945NSF.PCBP2.Hep-G2 227 bp overlap

ChIP Hep-G2 GSE120104.PCBP2.Hep-G2 220 bp overlap

PCGF1 2 datasets

ChIP WA01 GSE104690.PCGF1.WA01 223 bp overlap

ChIP WA01 GSE104690.PCGF1.WA01 74 bp overlap

POLR2A 3 datasets

ChIP GM23338 ENCFF450WCS 136 bp overlap

ChIP H1 ENCFF566JSR 431 bp overlap

ChIP H1 ENCFF833NJP 325 bp overlap

POU5F1 5 datasets

ChIP BG03 GSE21614.POU5F1.BG03 195 bp overlap

ChIP BG03 GSE21614.POU5F1.BG03 160 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 497 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 453 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 255 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 532 bp overlap

RAD21 2 datasets

ChIP H1 ENCFF967OJF 245 bp overlap

ChIP RH4 GSE83726.RAD21.RH4 197 bp overlap

RBBP4 2 datasets

ChIP RH5 GSE155861.RBBP4.RH5 281 bp overlap

ChIP SCMC GSE155861.RBBP4.SCMC 312 bp overlap

RBBP5 4 datasets

ChIP H1 ENCFF905HFL 429 bp overlap

ChIP H1 ENCFF905HFL 518 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 173 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 245 bp overlap

RREB1 1 dataset

Motif DE_12h DE_12h-RREB1_MA0073.2 19 bp overlap

RUNX2 1 dataset

ChIP Karpas-45 GSE151819.RUNX2.Karpas-45 181 bp overlap

ChIP WA01 GSE104690.RYBP.WA01 234 bp overlap

SIN3A 1 dataset

ChIP hiPSC_IB12 GSE106870.SIN3A.hiPSC_IB12 165 bp overlap

ChIP WTC11 ENCFF891HYW 377 bp overlap

SMAD2 3 datasets

ChIP hESC GSE29422.SMAD2.hESC 266 bp overlap

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 375 bp overlap

ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 295 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 363 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 325 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 346 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 386 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 418 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 328 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 376 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 264 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 352 bp overlap

SMAD3 3 datasets

ChIP BG03_DIFF_2H GSE36578.SMAD3.BG03_DIFF_2H 252 bp overlap

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 245 bp overlap

ChIP hESC GSE29422.SMAD3.hESC 292 bp overlap

SMAD4 1 dataset

ChIP hESC GSE29422.SMAD4.hESC 271 bp overlap

SMARCA4 9 datasets

ChIP CTV-1_DSG GSE128835.SMARCA4.CTV-1_DSG 532 bp overlap

ChIP CTV-1_DSG_SPI1-mut GSE128835.SMARCA4.CTV-1_DSG_SPI1-mut 422 bp overlap

ChIP CTV-1_FLAG GSE128835.SMARCA4.CTV-1_FLAG 382 bp overlap

ChIP CTV-1_FLAG_SPI1-mut GSE128835.SMARCA4.CTV-1_FLAG_SPI1-mut 522 bp overlap

ChIP CTV-1_delA GSE128835.SMARCA4.CTV-1_delA 275 bp overlap

ChIP CTV-1_delA GSE128835.SMARCA4.CTV-1_delA 108 bp overlap

ChIP CTV-1_delQ GSE128835.SMARCA4.CTV-1_delQ 218 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 272 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 247 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 460 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 124 bp overlap

SMARCC1 3 datasets

ChIP HS-SY-2 GSE108025.SMARCC1.HS-SY-2 487 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 481 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 224 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 181 bp overlap

ChIP WTC11 ENCFF688PEU 481 bp overlap

Motif DE_12h DE_12h-SP8_MA0747.2 11 bp overlap

Motif DE_12h DE_12h-SP8_MA0747.2 11 bp overlap

SPI1 4 datasets

ChIP CTV-1_FLAG_15perc GSE128835.SPI1.CTV-1_FLAG_15perc 487 bp overlap

ChIP CTV-1_delA GSE128835.SPI1.CTV-1_delA 365 bp overlap

ChIP CTV-1_delQ GSE128835.SPI1.CTV-1_delQ 505 bp overlap

ChIP CTV-1_delQA GSE128835.SPI1.CTV-1_delQA 349 bp overlap

SUPT5H 2 datasets

ChIP MOLT-4_NVP2 GSE89384.SUPT5H.MOLT-4_NVP2 276 bp overlap

ChIP MOLT-4_SNS GSE89384.SUPT5H.MOLT-4_SNS 303 bp overlap

TAF1 2 datasets

ChIP H1 ENCFF478SZO 396 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 327 bp overlap

ChIP WA01 ENCSR000ECB.TBP.WA01 229 bp overlap

ChIP hESC_10h GSE122298.TBP.hESC_10h 181 bp overlap

ChIP hESC_2h GSE122298.TBP.hESC_2h 259 bp overlap

ChIP hESC_8h GSE122298.TBP.hESC_8h 105 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 118 bp overlap

ChIP GEN2-2 GSE76147.TCF4.GEN2-2 241 bp overlap

TEAD1 1 dataset

ChIP WTC11 ENCFF502QUV 379 bp overlap

TEAD4 2 datasets

ChIP ESC S26-ESC-d0-TEAD4-exp1 276 bp overlap

ChIP H1 ENCFF778PAX 212 bp overlap

TGIF2 1 dataset

ChIP WTC11 ENCFF649SHI 425 bp overlap

ChIP breast-organoid GSE113909.TP63.breast-organoid 131 bp overlap

TRIM28 1 dataset

ChIP hESC GSE115387.TRIM28.hESC 178 bp overlap

ChIP ALL GSE145549.YY1.ALL 220 bp overlap

ChIP ALL GSE145549.YY1.ALL 175 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 151 bp overlap

ZBTB43 2 datasets

ChIP WTC11 ENCFF058JUB 450 bp overlap

ChIP WTC11 ENCFF058JUB 236 bp overlap

ChIP GM12878 ENCSR000BND.ZEB1.GM12878 141 bp overlap

ZFHX2 1 dataset

ChIP HEK293 ENCFF167TUA 450 bp overlap

Motif DE_12h DE_12h-ZIC1_MA0696.1 14 bp overlap

Motif DE_12h DE_12h-ZIC4_MA0751.2 14 bp overlap

Motif DE_12h DE_12h-ZIC5_MA1584.2 15 bp overlap

ZNF398 1 dataset

ChIP H9 GSE133630.ZNF398.H9 165 bp overlap

ZNF423 1 dataset

ChIP WTC11 ENCFF574PBR 317 bp overlap

ZNF462 2 datasets

ChIP GM23338 ENCFF896CCA 231 bp overlap

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 532 bp overlap