BMPR1A

BMPR1A

bone morphogenetic protein receptor type 1A | ALK3, CD292, ACVRLK3

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Member of: DE-2 DE-2.1

Biological processes 107 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)BMP binding (GO:0036122)BMP binding (GO:0036122)BMP receptor activity (GO:0098821)BMP receptor activity (GO:0098821)BMP receptor activity (GO:0098821)BMP signaling pathway (GO:0030509)BMP signaling pathway (GO:0030509)BMP signaling pathway (GO:0030509)BMP signaling pathway (GO:0030509)BMP signaling pathway (GO:0030509)HFE-transferrin receptor complex (GO:1990712)HFE-transferrin receptor complex (GO:1990712)SMAD binding (GO:0046332)SMAD binding (GO:0046332)angiogenesis (GO:0001525)anti-Mullerian hormone receptor signaling pathway (GO:1990262)anti-Mullerian hormone receptor signaling pathway (GO:1990262)atrioventricular node cell development (GO:0060928)atrioventricular node cell development (GO:0060928)atrioventricular valve development (GO:0003171)atrioventricular valve development (GO:0003171)cardiac conduction system development (GO:0003161)cardiac conduction system development (GO:0003161)cardiac right ventricle morphogenesis (GO:0003215)cardiac right ventricle morphogenesis (GO:0003215)caveola (GO:0005901)cell differentiation (GO:0030154)cell surface (GO:0009986)cell surface receptor protein serine/threonine kinase signaling pathway (GO:0007178)cellular response to BMP stimulus (GO:0071773)cellular response to growth factor stimulus (GO:0071363)chondrocyte differentiation (GO:0002062)dendrite (GO:0030425)dorsal aorta morphogenesis (GO:0035912)dorsal aorta morphogenesis (GO:0035912)dorsal/ventral pattern formation (GO:0009953)embryonic organ development (GO:0048568)endocardial cushion formation (GO:0003272)endocardial cushion morphogenesis (GO:0003203)endocardial cushion morphogenesis (GO:0003203)external side of plasma membrane (GO:0009897)fibrous ring of heart morphogenesis (GO:1905285)fibrous ring of heart morphogenesis (GO:1905285)immune response (GO:0006955)membrane (GO:0016020)membrane (GO:0016020)mitral valve morphogenesis (GO:0003183)mitral valve morphogenesis (GO:0003183)negative regulation of gene expression (GO:0010629)negative regulation of smooth muscle cell migration (GO:0014912)neuronal cell body (GO:0043025)osteoblast differentiation (GO:0001649)outflow tract morphogenesis (GO:0003151)outflow tract morphogenesis (GO:0003151)outflow tract septum morphogenesis (GO:0003148)outflow tract septum morphogenesis (GO:0003148)pharyngeal arch artery morphogenesis (GO:0061626)pharyngeal arch artery morphogenesis (GO:0061626)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of SMAD protein signal transduction (GO:0060391)positive regulation of SMAD protein signal transduction (GO:0060391)positive regulation of bone mineralization (GO:0030501)positive regulation of bone mineralization (GO:0030501)positive regulation of cardiac muscle cell proliferation (GO:0060045)positive regulation of cardiac muscle cell proliferation (GO:0060045)positive regulation of cardiac ventricle development (GO:1904414)positive regulation of cardiac ventricle development (GO:1904414)positive regulation of dendrite development (GO:1900006)positive regulation of gene expression (GO:0010628)positive regulation of miRNA transcription (GO:1902895)positive regulation of osteoblast differentiation (GO:0045669)positive regulation of osteoblast differentiation (GO:0045669)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transforming growth factor beta2 production (GO:0032915)positive regulation of vascular associated smooth muscle cell proliferation (GO:1904707)positive regulation of vascular associated smooth muscle cell proliferation (GO:1904707)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein kinase activity (GO:0004672)protein serine/threonine kinase activity (GO:0004674)regulation of cardiac muscle cell apoptotic process (GO:0010665)regulation of cardiac muscle cell proliferation (GO:0060043)regulation of cardiac muscle cell proliferation (GO:0060043)regulation of neural crest cell differentiation (GO:1905292)signaling receptor complex (GO:0043235)stem cell differentiation (GO:0048863)transforming growth factor beta receptor activity, type I (GO:0005025)transforming growth factor beta receptor activity, type I (GO:0005025)transforming growth factor beta receptor signaling pathway (GO:0007179)transforming growth factor beta receptor signaling pathway (GO:0007179)transmembrane receptor protein serine/threonine kinase activity (GO:0004675)transmembrane receptor protein serine/threonine kinase activity (GO:0004675)tricuspid valve morphogenesis (GO:0003186)tricuspid valve morphogenesis (GO:0003186)ventricular compact myocardium morphogenesis (GO:0003223)ventricular compact myocardium morphogenesis (GO:0003223)ventricular septum morphogenesis (GO:0060412)ventricular septum morphogenesis (GO:0060412)ventricular trabecula myocardium morphogenesis (GO:0003222)ventricular trabecula myocardium morphogenesis (GO:0003222)

Expression (TPM)

TFs regulating BMPR1A 0 TFs

Transcription factors with Perturb-seq knockdown data for BMPR1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BMPR1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to BMPR1A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BMPR1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr10:86,520,920–86,522,476	234.8 kb	Distal (>10kb) Multiome	901
	chr10:86,535,238–86,536,949	221.1 kb	Distal (>10kb) Multiome	617
	chr10:86,585,119–86,585,766	171.0 kb	Distal (>10kb) Multiome	421
	chr10:86,599,659–86,600,297	156.7 kb	Distal (>10kb) Multiome	111
	chr10:86,631,854–86,632,698	124.4 kb	Distal (>10kb) Multiome	226
	chr10:86,693,793–86,694,266	62.7 kb	Distal (>10kb) Multiome	132
	chr10:86,710,752–86,712,521	45.3 kb	Distal (>10kb) Multiome	898
	chr10:86,755,517–86,757,638	137 bp	At TSS Multiome	902
	chr10:86,864,876–86,866,168	108.6 kb	Distal (>10kb) Multiome	123
	chr10:86,939,081–86,939,963	182.9 kb	Distal (>10kb) Multiome	539
	chr10:86,953,950–86,955,264	197.9 kb	Distal (>10kb) Multiome	348
	chr10:86,959,879–86,960,855	203.9 kb	Distal (>10kb) Multiome	453
	chr10:86,966,444–86,967,440	210.3 kb	Distal (>10kb) Multiome	479
	chr10:86,969,969–86,972,224	214.8 kb	Distal (>10kb) Multiome	505
	chr10:87,054,811–87,055,712	298.6 kb	Distal (>10kb) Multiome	179

Genome Browser

Genomic view of the BMPR1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.