This gene encodes a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers. It is expressed in the liver, and is likely involved in transport. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for SLC25A17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:40,636,029–40,637,455 | 182.5 kb | Distal (>10kb) Multiome | 903 | |
| chr22:40,684,688–40,685,220 | 134.4 kb | Distal (>10kb) Multiome | 101 | |
| chr22:40,818,885–40,819,668 | 20 bp | At TSS Multiome | 683 | |
| chr22:40,856,149–40,857,393 | 37.5 kb | Distal (>10kb) Multiome | 950 | |
| chr22:40,950,581–40,952,237 | 132.1 kb | Distal (>10kb) Multiome | 884 | |
| chr22:41,021,558–41,023,199 | 202.7 kb | Distal (>10kb) Multiome | 978 | |
| chr22:41,091,127–41,092,906 | 272.3 kb | Distal (>10kb) Multiome | 880 |
Genomic view of the SLC25A17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.