Transcription factors with Perturb-seq knockdown data for ENSG00000289292. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289292 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289292, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:40,636,029–40,637,455 | 48.1 kb | Distal (>10kb) Multiome | 903 | |
| chr22:40,683,094–40,683,436 | 1.5 kb | Proximal (<10kb) | 465 | |
| chr22:40,684,688–40,685,220 | 19 bp | At TSS Multiome | 101 | |
| chr22:40,694,272–40,694,541 | 9.3 kb | Proximal (<10kb) | 42 | |
| chr22:40,818,885–40,819,668 | 134.4 kb | Distal (>10kb) Multiome | 683 | |
| chr22:40,856,149–40,857,393 | 171.9 kb | Distal (>10kb) Multiome | 950 | |
| chr22:40,950,581–40,952,237 | 266.5 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the ENSG00000289292 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.