The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for ST13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:39,519,211–39,521,337 | 1336.5 kb | Distal (>10kb) Multiome HiCAR | 1150 | |
| chr22:39,532,183–39,533,171 | 1323.8 kb | Distal (>10kb) Multiome HiCAR | 799 | |
| chr22:39,534,113–39,535,455 | 1321.7 kb | Distal (>10kb) Multiome HiCAR | 621 | |
| chr22:40,636,029–40,637,455 | 219.8 kb | Distal (>10kb) Multiome | 903 | |
| chr22:40,684,688–40,685,220 | 171.7 kb | Distal (>10kb) Multiome | 101 | |
| chr22:40,818,885–40,819,668 | 37.3 kb | Distal (>10kb) Multiome | 683 | |
| chr22:40,856,149–40,857,393 | 187 bp | At TSS Multiome | 950 | |
| chr22:40,950,581–40,952,237 | 94.8 kb | Distal (>10kb) Multiome | 884 | |
| chr22:41,021,558–41,023,199 | 165.4 kb | Distal (>10kb) Multiome | 978 | |
| chr22:41,091,127–41,092,906 | 235.0 kb | Distal (>10kb) Multiome | 880 | |
| chr22:42,365,301–42,366,142 | 1508.9 kb | Distal (>10kb) Multiome HiCAR | 197 | |
| chr22:42,368,263–42,369,908 | 1512.7 kb | Distal (>10kb) Multiome HiCAR | 592 |
Genomic view of the ST13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.