This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for RBX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:40,684,688–40,685,220 | 266.5 kb | Distal (>10kb) Multiome | 101 | |
| chr22:40,818,885–40,819,668 | 132.0 kb | Distal (>10kb) Multiome | 683 | |
| chr22:40,856,149–40,857,393 | 94.6 kb | Distal (>10kb) Multiome | 950 | |
| chr22:40,950,581–40,952,237 | 29 bp | At TSS Multiome | 884 | |
| chr22:41,021,558–41,023,199 | 70.7 kb | Distal (>10kb) Multiome | 978 | |
| chr22:41,091,127–41,092,906 | 140.2 kb | Distal (>10kb) Multiome | 880 | |
| chr22:41,197,028–41,198,019 | 246.2 kb | Distal (>10kb) Multiome | 640 | |
| chr22:41,204,902–41,205,619 | 253.9 kb | Distal (>10kb) Multiome | 640 | |
| chr22:41,237,372–41,238,796 | 286.5 kb | Distal (>10kb) Multiome | 302 |
Genomic view of the RBX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.