chr21:42,806,044–42,807,071

chr21 : 42,806,044 – 42,807,071

1,027 bp 113 TFs 6 linked genes

This 1.0 kb open chromatin element is linked to 6 target genes and is bound by 113 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
WDR4		72.9 kb	Distal	Multiome
NDUFV3		86.7 kb	Distal	Multiome
ERVH48-1		119.0 kb	Distal	Multiome
PDE9A		152.8 kb	Distal	Multiome
PKNOX1		168.0 kb	Distal	Multiome
CBS		269.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

113 transcription factors

ChIP MCF-7 GSE48930.AR.MCF-7 214 bp overlap

ARID1A 1 dataset

ChIP RMG-I GSE104545.ARID1A.RMG-I 73 bp overlap

ARNT::HIF1A 2 datasets

Motif DE_24h DE_24h-ARNTHIF1A_MA0259.2 5 bp overlap

Motif DE_72h DE_72h-ARNTHIF1A_MA0259.2 5 bp overlap

Atoh1 2 datasets

Motif DE_24h DE_24h-Atoh1_MA1467.3 7 bp overlap

Motif DE_72h DE_72h-Atoh1_MA1467.3 7 bp overlap

BCOR 2 datasets

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 280 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 179 bp overlap

ChIP H-1_DE GSE126661.BRD3.H-1_DE 324 bp overlap

ChIP VCaP_Darolutamide GSE148358.BRD4.VCaP_Darolutamide 232 bp overlap

ChIP K-562 ENCSR000ATU.CBX2.K-562 320 bp overlap

ChIP KB_IL GSE52469.CDK6.KB_IL 100 bp overlap

CEBPA 4 datasets

ChIP THP-1_1-25D_24h GSE124032.CEBPA.THP-1_1-25D_24h 94 bp overlap

ChIP THP-1_1-25D_8h GSE124032.CEBPA.THP-1_1-25D_8h 161 bp overlap

ChIP THP-1_EtOH_24h GSE124032.CEBPA.THP-1_EtOH_24h 194 bp overlap

ChIP THP-1_EtOH_2h GSE124032.CEBPA.THP-1_EtOH_2h 258 bp overlap

CREBBP 1 dataset

ChIP MCF-7 ERP000901.CREBBP.MCF-7 150 bp overlap

ChIP retina_Hu3 GSE137311.CRX.retina_Hu3 204 bp overlap

ChIP retina_Hu6 GSE137311.CRX.retina_Hu6 221 bp overlap

CTCF 2 datasets

ChIP THP-1_macrophage_PMA GSE96800.CTCF.THP-1_macrophage_PMA 114 bp overlap

ChIP retina_Hu22 GSE137311.CTCF.retina_Hu22 270 bp overlap

CTNNB1 1 dataset

ChIP hESC_activinA_15h GSE99202.CTNNB1.hESC_activinA_15h 285 bp overlap

Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 222 bp overlap

ChIP ProEs GSE59087.EED.ProEs 198 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 265 bp overlap

EP300 2 datasets

ChIP AML GSE131939.EP300.AML 317 bp overlap

ChIP AML_shaml1-eto GSE131939.EP300.AML_shaml1-eto 233 bp overlap

ChIP SKNO-1 GSE23730.ERG.SKNO-1 215 bp overlap

ChIP TSU-1621MT_ATRA GSE60477.ERG.TSU-1621MT_ATRA 241 bp overlap

ChIP VCaP GSE49091.ERG.VCaP 140 bp overlap

ESR1 2 datasets

ChIP MCF-7_aldosterone GSE99626.ESR1.MCF-7_aldosterone 283 bp overlap

ChIP MCF-7_ethanol_MKL1D200 GSE107476.ESR1.MCF-7_ethanol_MKL1D200 267 bp overlap

ETV6 2 datasets

ChIP WTC11 ENCFF812SCD 437 bp overlap

ChIP WTC11 ENCFF812SCD 437 bp overlap

FLI1 2 datasets

ChIP A-673_1_KRAB_GFP GSE106914.FLI1.A-673_1_KRAB_GFP 292 bp overlap

ChIP SKNO-1 GSE23730.FLI1.SKNO-1 412 bp overlap

FOXA1 1 dataset

ChIP VCaP_ETOH24H GSE58428.FOXA1.VCaP_ETOH24H 313 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 547 bp overlap

ChIP DE DE-FOXA2-2 367 bp overlap

FOXH1 1 dataset

Motif DE_72h DE_72h-FOXH1_MA0479.2 8 bp overlap

FOXP4 1 dataset

ChIP WTC11 ENCFF708TAF 377 bp overlap

GABPA 1 dataset

ChIP VCaP GSE49091.GABPA.VCaP 134 bp overlap

GATA2 1 dataset

ChIP ME-1_CBFB-MYH11-KD GSE117138.GATA2.ME-1_CBFB-MYH11-KD 293 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 602 bp overlap

ChIP DE DE-GATA4-2 838 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 562 bp overlap

ChIP DE DE-GATA6-2 865 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 750 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 731 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 705 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 133 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 543 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 699 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 661 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 396 bp overlap

ChIP foregut GSE117136.GATA6.foregut 273 bp overlap

Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap

Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap

HAND2 2 datasets

Motif DE_24h DE_24h-HAND2_MA1638.2 6 bp overlap

Motif DE_72h DE_72h-HAND2_MA1638.2 6 bp overlap

HDAC1 1 dataset

ChIP PC-3 GSE147455.HDAC1.PC-3 171 bp overlap

HIF1A 2 datasets

Motif DE_24h DE_24h-HIF1A_MA1106.2 6 bp overlap

Motif DE_72h DE_72h-HIF1A_MA1106.2 6 bp overlap

HNF1B 1 dataset

ChIP Hep-G2 ENCSR127XTZ.HNF1B.Hep-G2 251 bp overlap

JARID2 1 dataset

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 281 bp overlap

JMJD1C 1 dataset

ChIP THP-1 GSE63484.JMJD1C.THP-1 193 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 749 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 504 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 868 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 800 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 406 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 503 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 723 bp overlap

KDM4A 1 dataset

ChIP hiPSC_IIA11 GSE106870.KDM4A.hiPSC_IIA11 174 bp overlap

LDB1 2 datasets

ChIP Kasumi-1_ctrl GSE121280.LDB1.Kasumi-1_ctrl 191 bp overlap

ChIP Kasumi-1_siRE GSE121280.LDB1.Kasumi-1_siRE 251 bp overlap

ChIP Kasumi-1_SICTR GSE60130.LMO2.Kasumi-1_SICTR 146 bp overlap

MED1 3 datasets

ChIP HCT-116_shLuc_thaps GSE121798.MED1.HCT-116_shLuc_thaps 57 bp overlap

ChIP VCaP GSE148358.MED1.VCaP 311 bp overlap

ChIP VCaP_R1881 GSE148358.MED1.VCaP_R1881 218 bp overlap

MED26 1 dataset

ChIP HEK293T GSE121024.MED26.HEK293T 221 bp overlap

MEIS1 1 dataset

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

NANOG 8 datasets

ChIP GM23338 ENCFF065NZG 311 bp overlap

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 161 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 639 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 315 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 654 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 334 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 256 bp overlap

ChIP hESC GSE18292.NANOG.hESC 199 bp overlap

NCAPH2 1 dataset

ChIP RMG-I GSE120058.NCAPH2.RMG-I 156 bp overlap

NEUROD1 5 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 182 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 193 bp overlap

ChIP D341-Med_shNEUROD1-1154 GSE92582.NEUROD1.D341-Med_shNEUROD1-1154 156 bp overlap

Motif DE_24h DE_24h-NEUROD1_MA1109.2 8 bp overlap

Motif DE_72h DE_72h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 2 datasets

Motif DE_24h DE_24h-NEUROG2_MA1642.2 7 bp overlap

Motif DE_72h DE_72h-NEUROG2_MA1642.2 7 bp overlap

ChIP ProEs GSE59087.NFE2.ProEs 123 bp overlap

NR2C1 2 datasets

Motif DE_24h DE_24h-NR2C1_MA1535.2 6 bp overlap

Motif DE_72h DE_72h-NR2C1_MA1535.2 6 bp overlap

NR2C2 2 datasets

Motif DE_24h DE_24h-NR2C2_MA1536.2 6 bp overlap

Motif DE_72h DE_72h-NR2C2_MA1536.2 6 bp overlap

NR2F1 2 datasets

Motif DE_24h DE_24h-NR2F1_MA1537.2 13 bp overlap

Motif DE_72h DE_72h-NR2F1_MA1537.2 13 bp overlap

Neurod2 2 datasets

Motif DE_24h DE_24h-Neurod2_MA0668.3 8 bp overlap

Motif DE_72h DE_72h-Neurod2_MA0668.3 8 bp overlap

Nr1H2 2 datasets

Motif DE_24h DE_24h-Nr1H2_MA1996.2 6 bp overlap

Motif DE_72h DE_72h-Nr1H2_MA1996.2 6 bp overlap

Nr1H4 2 datasets

Motif DE_24h DE_24h-Nr1H4_MA1110.3 6 bp overlap

Motif DE_72h DE_72h-Nr1H4_MA1110.3 6 bp overlap

Nr1h3 2 datasets

Motif DE_24h DE_24h-Nr1h3_MA2337.1 6 bp overlap

Motif DE_72h DE_72h-Nr1h3_MA2337.1 6 bp overlap

Nr1h3::Rxra 2 datasets

Motif DE_24h DE_24h-Nr1h3Rxra_MA0494.2 16 bp overlap

Motif DE_72h DE_72h-Nr1h3Rxra_MA0494.2 16 bp overlap

Nr2f6 2 datasets

Motif DE_24h DE_24h-Nr2f6_MA0677.2 13 bp overlap

Motif DE_72h DE_72h-Nr2f6_MA0677.2 13 bp overlap

Motif DE_72h DE_72h-OSR2_MA1646.2 8 bp overlap

Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap

ChIP retina_Hu7 GSE137311.OTX2.retina_Hu7 351 bp overlap

PITX1 1 dataset

Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap

PITX3 1 dataset

Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap

POU5F1 5 datasets

ChIP BG03 GSE21614.POU5F1.BG03 193 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 800 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 531 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 343 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 183 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 742 bp overlap

PPARD 2 datasets

Motif DE_24h DE_24h-PPARD_MA1550.2 14 bp overlap

Motif DE_72h DE_72h-PPARD_MA1550.2 14 bp overlap

Pou5f1::Sox2 1 dataset

Motif DE_72h DE_72h-Pou5f1Sox2_MA0142.1 15 bp overlap

Pparg::Rxra 2 datasets

Motif DE_24h DE_24h-PpargRxra_MA0065.3 13 bp overlap

Motif DE_72h DE_72h-PpargRxra_MA0065.3 13 bp overlap

ChIP KB_IL GSE52469.RELA.KB_IL 111 bp overlap

ChIP hippocampus GSE144226.REST.hippocampus 344 bp overlap

RHOXF1 1 dataset

Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap

ChIP retina_Hu22 GSE137311.RORB.retina_Hu22 232 bp overlap

RUNX1 2 datasets

ChIP Kasumi-1 GSE45738.RUNX1.Kasumi-1 361 bp overlap

ChIP SKH1_RUNX1-EVI1_KD GSE87283.RUNX1.SKH1_RUNX1-EVI1_KD 136 bp overlap

RUNX1T1 1 dataset

ChIP Kasumi-1 GSE102697.RUNX1T1.Kasumi-1 180 bp overlap

RXRA::VDR 2 datasets

Motif DE_24h DE_24h-RXRAVDR_MA0074.1 15 bp overlap

Motif DE_72h DE_72h-RXRAVDR_MA0074.1 15 bp overlap

SMAD1 1 dataset

ChIP Hep-G2 ENCSR213QOZ.SMAD1.Hep-G2 82 bp overlap

SMAD2 2 datasets

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 556 bp overlap

ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 361 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 442 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 691 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 702 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 712 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 852 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 798 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 838 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 533 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 738 bp overlap

SMAD3 3 datasets

ChIP BG03 GSE21614.SMAD3.BG03 241 bp overlap

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 161 bp overlap

ChIP hESC GSE29422.SMAD3.hESC 157 bp overlap

SMARCB1 1 dataset

ChIP MCF-7 GSE123284.SMARCB1.MCF-7 221 bp overlap

SMARCC1 3 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 490 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 374 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 168 bp overlap

SMC1A 1 dataset

ChIP monocyte_INFg GSE98367.SMC1A.monocyte_INFg 230 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 340 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 947 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 254 bp overlap

SOX21 1 dataset

ChIP neuroepithelilal-cells GSE110505.SOX21.neuroepithelilal-cells 301 bp overlap

SPI1 5 datasets

ChIP CD34_FETAL GSE70660.SPI1.CD34_FETAL 156 bp overlap

ChIP CTV-1_FLAG_15perc GSE128835.SPI1.CTV-1_FLAG_15perc 214 bp overlap

ChIP Kasumi-1_SICTR GSE60130.SPI1.Kasumi-1_SICTR 148 bp overlap

ChIP Kasumi-1_SIRUNX1ETO GSE60130.SPI1.Kasumi-1_SIRUNX1ETO 206 bp overlap

ChIP primary-monocyte_18h_donorO GSE128834.SPI1.primary-monocyte_18h_donorO 277 bp overlap

SS18-SSX 1 dataset

ChIP fibroblast_W164A GSE139053.SS18-SSX.fibroblast_W164A 58 bp overlap

STAT3 2 datasets

ChIP MCF-7_jc5838 GSE126004.STAT3.MCF-7_jc5838 201 bp overlap

ChIP MCF-7_jc5843 GSE126004.STAT3.MCF-7_jc5843 265 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 241 bp overlap

ChIP hESC_10h GSE122298.TBP.hESC_10h 154 bp overlap

TCF12 1 dataset

ChIP Kasumi-1 GSE23730.TCF12.Kasumi-1 239 bp overlap

ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 278 bp overlap

TEAD4 1 dataset

ChIP hESC GSE99202.TEAD4.hESC 208 bp overlap

TFAP2C 1 dataset

ChIP HCC1954 GSE126897.TFAP2C.HCC1954 220 bp overlap

THAP1 1 dataset

ChIP K-562 ENCSR000BNN.THAP1.K-562 97 bp overlap

THRB 2 datasets

Motif DE_24h DE_24h-THRB_MA1574.2 13 bp overlap

Motif DE_72h DE_72h-THRB_MA1574.2 13 bp overlap

TP53 2 datasets

ChIP H9 GSE142050.TP53.H9 568 bp overlap

ChIP H9_mesoderm GSE142050.TP53.H9_mesoderm 589 bp overlap

TRIM28 1 dataset

ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 472 bp overlap

TWIST1 2 datasets

Motif DE_24h DE_24h-TWIST1_MA1123.3 8 bp overlap

Motif DE_72h DE_72h-TWIST1_MA1123.3 8 bp overlap

ZBTB7A 1 dataset

ChIP VCaP_FBS GSE123089.ZBTB7A.VCaP_FBS 182 bp overlap

ZFP42 1 dataset

ChIP HEK293 GSE76494.ZFP42.HEK293 140 bp overlap

ZNF175 1 dataset

ChIP HEK293 GSE76494.ZNF175.HEK293 152 bp overlap

ZNF207 1 dataset

ChIP WA09 GSE118632.ZNF207.WA09 370 bp overlap

ZNF211 2 datasets

Motif DE_24h DE_24h-ZNF211_MA1974.2 10 bp overlap

Motif DE_72h DE_72h-ZNF211_MA1974.2 10 bp overlap

ZNF354C 1 dataset

Motif DE_72h DE_72h-ZNF354C_MA0130.1 6 bp overlap

ZNF449 1 dataset

Motif DE_72h DE_72h-ZNF449_MA1656.2 10 bp overlap

ZNF462 1 dataset

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 231 bp overlap

ZNF528 1 dataset

ChIP HEK293 GSE76494.ZNF528.HEK293 477 bp overlap

ZNF572 1 dataset

ChIP Hep-G2 ENCSR663CTC.ZNF572.Hep-G2 172 bp overlap