The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for JMJD1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JMJD1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JMJD1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:63,132,822–63,134,026 | 332.7 kb | Distal (>10kb) Multiome | 964 | |
| chr10:63,265,220–63,265,384 | 3.9 kb | Proximal (<10kb) | 253 | |
| chr10:63,267,805–63,267,971 | 1.3 kb | Proximal (<10kb) | 267 | |
| chr10:63,268,784–63,269,452 | 196.9 kb | Distal (>10kb) Multiome | 834 | |
| chr10:63,347,833–63,349,212 | 117.4 kb | Distal (>10kb) Multiome | 254 | |
| chr10:63,464,884–63,466,465 | 47 bp | At TSS Multiome | 987 | |
| chr10:63,469,132–63,469,618 | 3.2 kb | Proximal (<10kb) | 43 | |
| chr10:63,475,498–63,476,184 | 9.9 kb | Proximal (<10kb) Multiome | 164 | |
| chr10:63,520,698–63,522,345 | 55.5 kb | Distal (>10kb) Multiome | 966 | |
| chr10:63,629,052–63,631,108 | 164.6 kb | Distal (>10kb) Multiome | 968 | |
| chr10:63,713,131–63,714,105 | 247.5 kb | Distal (>10kb) Multiome HiCAR | 440 |
Genomic view of the JMJD1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.