The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NDUFV3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFV3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFV3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:42,593,112–42,593,723 | 299.9 kb | Distal (>10kb) Multiome HiCAR | 299 | |
| chr21:42,652,544–42,654,689 | 239.7 kb | Distal (>10kb) Multiome | 510 | |
| chr21:42,793,699–42,794,977 | 99.3 kb | Distal (>10kb) Multiome | 52 | |
| chr21:42,806,044–42,807,071 | 86.7 kb | Distal (>10kb) Multiome | 113 | |
| chr21:42,878,621–42,880,078 | 13.8 kb | Distal (>10kb) Multiome | 989 | |
| chr21:42,892,360–42,893,974 | 113 bp | At TSS Multiome | 992 | |
| chr21:42,923,670–42,924,528 | 30.8 kb | Distal (>10kb) Multiome | 542 | |
| chr21:42,925,494–42,925,953 | 32.5 kb | Distal (>10kb) Multiome | 42 | |
| chr21:42,936,514–42,937,904 | 44.3 kb | Distal (>10kb) Multiome | 182 | |
| chr21:42,955,489–42,956,014 | 62.5 kb | Distal (>10kb) Multiome | 345 | |
| chr21:42,956,807–42,957,632 | 63.9 kb | Distal (>10kb) Multiome | 172 | |
| chr21:42,972,793–42,975,770 | 81.1 kb | Distal (>10kb) Multiome | 945 | |
| chr21:43,659,125–43,659,916 | 766.3 kb | Distal (>10kb) Multiome HiCAR | 989 |
Genomic view of the NDUFV3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.