This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for PPARD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPARD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPARD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:35,141,228–35,141,736 | 201.2 kb | Distal (>10kb) Multiome | 171 | |
| chr6:35,193,064–35,193,865 | 149.0 kb | Distal (>10kb) Multiome | 107 | |
| chr6:35,213,536–35,214,675 | 128.5 kb | Distal (>10kb) Multiome | 310 | |
| chr6:35,258,904–35,260,476 | 82.8 kb | Distal (>10kb) Multiome | 1142 | |
| chr6:35,297,619–35,298,109 | 44.8 kb | Distal (>10kb) Multiome | 765 | |
| chr6:35,317,884–35,318,871 | 24.1 kb | Distal (>10kb) Multiome | 727 | |
| chr6:35,342,126–35,343,068 | 52 bp | At TSS Multiome | 831 | |
| chr6:35,451,927–35,453,018 | 109.7 kb | Distal (>10kb) Multiome HiCAR | 799 | |
| chr6:35,467,935–35,469,331 | 125.8 kb | Distal (>10kb) Multiome HiCAR | 1091 | |
| chr6:35,485,138–35,486,890 | 143.9 kb | Distal (>10kb) Multiome | 400 | |
| chr6:35,490,011–35,490,813 | 147.8 kb | Distal (>10kb) Multiome | 310 | |
| chr6:35,495,972–35,498,486 | 154.6 kb | Distal (>10kb) Multiome | 939 | |
| chr6:35,522,668–35,523,295 | 180.4 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the PPARD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.