This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NR2C1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NR2C1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NR2C1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:94,815,972–94,816,516 | 257.5 kb | Distal (>10kb) Multiome | 183 | |
| chr12:94,872,875–94,874,146 | 199.9 kb | Distal (>10kb) Multiome | 358 | |
| chr12:95,003,172–95,003,905 | 69.9 kb | Distal (>10kb) Multiome | 875 | |
| chr12:95,072,721–95,073,838 | 11 bp | At TSS Multiome | 927 | |
| chr12:95,129,410–95,130,455 | 56.6 kb | Distal (>10kb) Multiome | 158 | |
| chr12:95,216,693–95,218,575 | 144.0 kb | Distal (>10kb) Multiome | 1001 |
Genomic view of the NR2C1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.