This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for WDR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:42,593,112–42,593,723 | 286.1 kb | Distal (>10kb) Multiome | 299 | |
| chr21:42,652,544–42,654,689 | 225.9 kb | Distal (>10kb) Multiome | 510 | |
| chr21:42,793,699–42,794,977 | 85.5 kb | Distal (>10kb) Multiome | 52 | |
| chr21:42,806,044–42,807,071 | 72.9 kb | Distal (>10kb) Multiome | 113 | |
| chr21:42,878,621–42,880,078 | 67 bp | At TSS Multiome | 989 | |
| chr21:42,892,360–42,893,974 | 13.7 kb | Distal (>10kb) Multiome | 992 | |
| chr21:42,923,670–42,924,528 | 44.6 kb | Distal (>10kb) Multiome | 542 | |
| chr21:42,925,494–42,925,953 | 46.2 kb | Distal (>10kb) Multiome | 42 | |
| chr21:42,936,514–42,937,904 | 58.0 kb | Distal (>10kb) Multiome | 182 | |
| chr21:42,955,489–42,956,014 | 76.2 kb | Distal (>10kb) Multiome | 345 | |
| chr21:42,956,807–42,957,632 | 77.7 kb | Distal (>10kb) Multiome | 172 | |
| chr21:42,972,793–42,975,770 | 94.9 kb | Distal (>10kb) Multiome | 945 |
Genomic view of the WDR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.