ZNF211

zinc finger protein 211 | CH2H2-25, ZNF-25

This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Biological processes 7 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)negative regulation of DNA-templated transcription (GO:0045892)nucleus (GO:0005634)nucleus (GO:0005634)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF211 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF211. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF211 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF211

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF211, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:57,350,874–57,351,693	282.0 kb	Distal (>10kb) Multiome	620
chr19:57,362,957–57,363,972	269.8 kb	Distal (>10kb) Multiome	697
chr19:57,389,420–57,390,542	243.3 kb	Distal (>10kb) Multiome	722
chr19:57,410,944–57,411,658	222.0 kb	Distal (>10kb) Multiome	612
chr19:57,434,797–57,436,077	197.8 kb	Distal (>10kb) Multiome	742
chr19:57,477,251–57,477,789	155.6 kb	Distal (>10kb) Multiome	582
chr19:57,487,570–57,488,036	145.4 kb	Distal (>10kb) Multiome	483
chr19:57,499,726–57,500,208	133.3 kb	Distal (>10kb) Multiome	523
chr19:57,527,148–57,527,898	105.8 kb	Distal (>10kb) Multiome	711
chr19:57,559,528–57,559,978	73.4 kb	Distal (>10kb) Multiome	564
chr19:57,578,473–57,579,216	54.2 kb	Distal (>10kb) Multiome	668
chr19:57,583,416–57,584,426	49.2 kb	Distal (>10kb) Multiome	462
chr19:57,599,699–57,600,175	33.3 kb	Distal (>10kb) Multiome	646
chr19:57,614,049–57,614,534	18.9 kb	Distal (>10kb) Multiome	661
chr19:57,632,786–57,633,679	at TSS	At TSS Multiome	652
chr19:57,681,556–57,682,393	48.8 kb	Distal (>10kb) Multiome	724
chr19:57,708,682–57,709,450	76.0 kb	Distal (>10kb) Multiome	199
chr19:57,727,326–57,727,941	94.5 kb	Distal (>10kb) Multiome	400
chr19:57,746,610–57,747,111	113.6 kb	Distal (>10kb) Multiome	625
chr19:57,769,422–57,770,058	136.5 kb	Distal (>10kb) Multiome	509
chr19:57,803,547–57,804,316	170.7 kb	Distal (>10kb) Multiome	206
chr19:57,804,773–57,805,214	171.9 kb	Distal (>10kb) Multiome	37
chr19:57,810,480–57,811,177	177.6 kb	Distal (>10kb) Multiome	180
chr19:57,814,439–57,815,270	181.8 kb	Distal (>10kb) Multiome	692
chr19:57,819,268–57,819,991	186.5 kb	Distal (>10kb) Multiome	734
chr19:57,829,187–57,830,712	197.1 kb	Distal (>10kb) Multiome	321
chr19:57,849,421–57,850,221	216.6 kb	Distal (>10kb) Multiome	291
chr19:57,887,264–57,887,897	254.4 kb	Distal (>10kb) Multiome	47
chr19:57,888,389–57,889,457	255.9 kb	Distal (>10kb) Multiome	322
chr19:57,916,199–57,917,124	283.6 kb	Distal (>10kb) Multiome	535
chr19:58,150,278–58,150,941	517.5 kb	Distal (>10kb) Multiome HiCAR	533
chr19:58,154,448–58,155,527	521.9 kb	Distal (>10kb) Multiome HiCAR	802

Genome Browser

Genomic view of the ZNF211 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.