OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for OSR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:98,939,766–98,942,896 | 1.5 kb | Proximal (<10kb) | 801 | |
| chr8:98,944,134–98,945,767 | at TSS | At TSS | 736 | |
| chr8:98,947,167–98,948,851 | 2.8 kb | Proximal (<10kb) | 160 | |
| chr8:98,950,281–98,950,476 | 5.9 kb | Proximal (<10kb) | 37 | |
| chr8:98,951,052–98,951,938 | 6.7 kb | Proximal (<10kb) | 211 |
Genomic view of the OSR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.