Enables sequence-specific double-stranded DNA binding activity. Involved in female gonad development and male gonad development. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFP42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFP42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFP42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:186,554,397–186,556,441 | 1440.4 kb | Distal (>10kb) Multiome HiCAR | 443 | |
| chr4:187,994,010–187,994,481 | 1.3 kb | Proximal (<10kb) | 70 | |
| chr4:187,995,145–187,996,086 | 139 bp | At TSS Multiome | 219 | |
| chr4:187,996,492–187,997,331 | 1.1 kb | Proximal (<10kb) Multiome | 135 | |
| chr4:187,998,030–187,998,323 | 2.3 kb | Proximal (<10kb) | 2 | |
| chr4:188,031,743–188,032,849 | 36.6 kb | Distal (>10kb) Multiome | 242 | |
| chr4:188,107,786–188,108,710 | 112.5 kb | Distal (>10kb) Multiome | 196 | |
| chr4:188,195,903–188,196,923 | 200.6 kb | Distal (>10kb) Multiome HiCAR | 183 | |
| chr4:188,282,317–188,283,412 | 287.1 kb | Distal (>10kb) Multiome | 187 | |
| chr4:188,399,544–188,400,371 | 404.2 kb | Distal (>10kb) Multiome HiCAR | 207 |
Genomic view of the ZFP42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.