This gene is a member of the PEPP subfamily of paired-like homoebox genes. The gene may be regulated by androgens and epigenetic mechanisms. The encoded nuclear protein is likely a transcription factor that may play a role in human reproduction. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for RHOXF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHOXF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHOXF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:119,943,211–119,943,921 | 301.6 kb | Distal (>10kb) Multiome HiCAR | 763 | |
| chrX:120,244,717–120,245,389 | at TSS | At TSS | 746 | |
| chrX:120,250,502–120,251,241 | 5.5 kb | Proximal (<10kb) Multiome | 662 | |
| chrX:120,309,330–120,309,857 | 64.4 kb | Distal (>10kb) Multiome | 479 | |
| chrX:120,468,789–120,469,502 | 224.0 kb | Distal (>10kb) Multiome | 589 | |
| chrX:120,485,807–120,486,482 | 240.9 kb | Distal (>10kb) Multiome | 698 |
Genomic view of the RHOXF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.