The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MED26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MED26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MED26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:16,471,332–16,472,638 | 156.1 kb | Distal (>10kb) Multiome | 645 | |
| chr19:16,495,870–16,496,694 | 131.9 kb | Distal (>10kb) Multiome | 780 | |
| chr19:16,541,995–16,543,080 | 85.7 kb | Distal (>10kb) Multiome | 880 | |
| chr19:16,571,833–16,572,764 | 55.7 kb | Distal (>10kb) Multiome | 814 | |
| chr19:16,627,176–16,629,209 | 162 bp | At TSS Multiome | 896 | |
| chr19:16,659,555–16,661,823 | 31.9 kb | Distal (>10kb) Multiome | 987 | |
| chr19:16,828,911–16,830,011 | 201.2 kb | Distal (>10kb) Multiome | 623 | |
| chr19:16,895,945–16,898,066 | 269.1 kb | Distal (>10kb) Multiome | 632 |
Genomic view of the MED26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.