The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PDE9A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDE9A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDE9A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:42,495,806–42,497,032 | 157.4 kb | Distal (>10kb) Multiome | 588 | |
| chr21:42,513,219–42,514,906 | 140.1 kb | Distal (>10kb) Multiome | 484 | |
| chr21:42,593,112–42,593,723 | 60.4 kb | Distal (>10kb) Multiome | 299 | |
| chr21:42,652,544–42,654,689 | 153 bp | At TSS Multiome | 510 | |
| chr21:42,655,738–42,655,904 | 2.0 kb | Proximal (<10kb) | 57 | |
| chr21:42,793,699–42,794,977 | 140.2 kb | Distal (>10kb) Multiome | 52 | |
| chr21:42,806,044–42,807,071 | 152.8 kb | Distal (>10kb) Multiome | 113 | |
| chr21:42,878,621–42,880,078 | 225.7 kb | Distal (>10kb) Multiome | 989 | |
| chr21:42,892,360–42,893,974 | 239.4 kb | Distal (>10kb) Multiome | 992 | |
| chr21:42,923,670–42,924,528 | 270.3 kb | Distal (>10kb) Multiome | 542 | |
| chr21:42,925,494–42,925,953 | 272.0 kb | Distal (>10kb) Multiome | 42 | |
| chr21:42,936,514–42,937,904 | 283.8 kb | Distal (>10kb) Multiome | 182 |
Genomic view of the PDE9A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.