Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of sprouting angiogenesis. Located in cytoplasm; nuclear membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF354C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF354C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF354C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:178,778,843–178,779,399 | 281.3 kb | Distal (>10kb) Multiome | 165 | |
| chr5:178,859,723–178,860,476 | 200.4 kb | Distal (>10kb) Multiome | 813 | |
| chr5:178,895,613–178,896,587 | 164.4 kb | Distal (>10kb) Multiome | 509 | |
| chr5:178,994,469–178,995,315 | 65.5 kb | Distal (>10kb) Multiome | 118 | |
| chr5:179,023,550–179,024,208 | 36.6 kb | Distal (>10kb) Multiome | 632 | |
| chr5:179,060,130–179,060,668 | 17 bp | At TSS Multiome | 376 | |
| chr5:179,166,799–179,167,598 | 106.9 kb | Distal (>10kb) Multiome | 276 | |
| chr5:179,343,699–179,345,989 | 283.8 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the ZNF354C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.