chr12:120,822,842–120,823,717

chr12 : 120,822,842 – 120,823,717

875 bp 117 TFs 8 linked genes

This 875 bp open chromatin element is linked to 8 target genes and is bound by 117 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
SPPL3		81.2 kb	Distal	Multiome
ACADS		97.4 kb	Distal	Multiome
UNC119B		112.7 kb	Distal	Multiome
MLEC		136.0 kb	Distal	Multiome
C12orf43		193.3 kb	Distal	Multiome
POP5		241.8 kb	Distal	Multiome
RNF10		288.8 kb	Distal	Multiome
COQ5		294.0 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

117 transcription factors

ChIP LNCaP_Bag-1L_WT_DHT GSE89938.AR.LNCaP_Bag-1L_WT_DHT 154 bp overlap

ASCL1 2 datasets

ChIP NCI-H2107 GSE69394.ASCL1.NCI-H2107 138 bp overlap

ChIP SCLC_ASCLP GSE61197.ASCL1.SCLC_ASCLP 200 bp overlap

ASXL3 1 dataset

ChIP NCI-H1963_Ab1 GSE145028.ASXL3.NCI-H1963_Ab1 204 bp overlap

ChIP K562 ENCFF469GPI 431 bp overlap

Arid3a 1 dataset

Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BAP1.NCI-H1963_shNONT 834 bp overlap

BCL11A 1 dataset

ChIP WA01 ENCSR000BIP.BCL11A.WA01 116 bp overlap

BRD4 3 datasets

ChIP NCI-H1963 GSE145028.BRD4.NCI-H1963 581 bp overlap

ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 875 bp overlap

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 743 bp overlap

Bach1::Mafk 1 dataset

Motif DE_72h DE_72h-Bach1Mafk_MA0591.2 12 bp overlap

CEBPB 6 datasets

ChIP H1 ENCFF871PTR 261 bp overlap

ChIP Ishikawa ENCFF010USJ 261 bp overlap

ChIP Ishikawa ENCSR000BTT.CEBPB.Ishikawa 154 bp overlap

ChIP K-562 ENCSR000BRQ.CEBPB.K-562 127 bp overlap

ChIP K562 ENCFF584CTB 65 bp overlap

ChIP WA01 ENCSR000EBV.CEBPB.WA01 269 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 132 bp overlap

CTCF 3 datasets

ChIP GM12878 ENCFF511URZ 205 bp overlap

ChIP OCI-LY1 ENCFF455ESK 401 bp overlap

ChIP OCI-Ly1 ENCSR072EUE.CTCF.OCI-Ly1 292 bp overlap

Dmrt1 1 dataset

Motif DE_72h DE_72h-Dmrt1_MA1603.2 9 bp overlap

ChIP K-562 ENCSR000BNE.EGR1.K-562 148 bp overlap

EOMES 2 datasets

ChIP hESC GSE26097.EOMES.hESC 296 bp overlap

ChIP hESC GSE26097.EOMES.hESC 212 bp overlap

EP300 1 dataset

ChIP WA01 ENCSR000BKK.EP300.WA01 161 bp overlap

ESR1 5 datasets

ChIP Ishikawa ENCSR000BIY.ESR1.Ishikawa 186 bp overlap

ChIP Ishikawa_C1-5 GSE147141.ESR1.Ishikawa_C1-5 227 bp overlap

ChIP Ishikawa_ETV4-KO2_Mili GSE129803.ESR1.Ishikawa_ETV4-KO2_Mili 245 bp overlap

ChIP MDA-MB-134-VI_ESTROGEN GSE51022.ESR1.MDA-MB-134-VI_ESTROGEN 490 bp overlap

ChIP endometrioid-adenocarcinoma_tumor_3 GSE94031.ESR1.endometrioid-adenocarcinoma_tumor_3 257 bp overlap

ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 249 bp overlap

FIGLA 2 datasets

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap

FOXA1 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 226 bp overlap

FOXA2 4 datasets

ChIP DE DE-FOXA2-1 794 bp overlap

ChIP DE DE-FOXA2-2 875 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 213 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 388 bp overlap

FOXD2 1 dataset

Motif DE_72h DE_72h-FOXD2_MA0847.4 11 bp overlap

FOXD3 1 dataset

Motif DE_72h DE_72h-FOXD3_MA0041.3 14 bp overlap

GATA4 9 datasets

ChIP A-549 GSE85002.GATA4.A-549 311 bp overlap

ChIP DE DE-GATA4-1 313 bp overlap

ChIP DE DE-GATA4-1 346 bp overlap

ChIP DE DE-GATA4-2 846 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 352 bp overlap

ChIP foregut GSE117136.GATA4.foregut 230 bp overlap

ChIP foregut GSE117136.GATA4.foregut 387 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 473 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 333 bp overlap

GATA6 12 datasets

ChIP DE DE-GATA6-1 309 bp overlap

ChIP DE DE-GATA6-1 344 bp overlap

ChIP DE DE-GATA6-2 875 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 218 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 322 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 296 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 256 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 288 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 305 bp overlap

ChIP foregut GSE117136.GATA6.foregut 216 bp overlap

ChIP foregut GSE117136.GATA6.foregut 334 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 409 bp overlap

Motif DE_72h DE_72h-GLI3_MA1491.3 15 bp overlap

GLIS1 3 datasets

Motif DE_72h DE_72h-GLIS1_MA0735.2 15 bp overlap

ChIP HEK293 ENCFF299RSE 263 bp overlap

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 302 bp overlap

GLIS3 2 datasets

Motif DE_72h DE_72h-GLIS3_MA0737.1 14 bp overlap

ChIP H9_plus GSE109562.GLIS3.H9_plus 445 bp overlap

Motif DE_72h DE_72h-Gli2_MA0734.4 9 bp overlap

HDAC2 3 datasets

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 211 bp overlap

ChIP WA01 ENCSR000BNR.HDAC2.WA01 115 bp overlap

HNF4A 1 dataset

Motif DE_72h DE_72h-HNF4A_MA0114.5 9 bp overlap

HNF4G 1 dataset

Motif DE_72h DE_72h-HNF4G_MA0484.3 9 bp overlap

HNRNPK 1 dataset

ChIP Hep-G2 GSE120104.HNRNPK.Hep-G2 196 bp overlap

IKZF1 3 datasets

ChIP K-562 ENCSR395HWC.IKZF1.K-562 361 bp overlap

ChIP K562 ENCFF348IBL 318 bp overlap

ChIP K562 ENCFF771OHZ 145 bp overlap

IKZF3 2 datasets

ChIP HEK293 ENCFF518OXG 371 bp overlap

ChIP HEK293 ENCSR304AMN.IKZF3.HEK293 316 bp overlap

ChIP GM12878 ENCSR000BGY.IRF4.GM12878 142 bp overlap

ChIP H1 ENCFF010YXS 234 bp overlap

KDM1A 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.KDM1A.pancreatic-progenitor_PP1 198 bp overlap

KDM4A 1 dataset

ChIP hiPSC_IA12 GSE106870.KDM4A.hiPSC_IA12 165 bp overlap

Motif DE_72h DE_72h-Lhx3_MA0135.2 12 bp overlap

Motif DE_72h DE_72h-MAFK_MA0496.4 10 bp overlap

ChIP H1 ENCFF601FOM 313 bp overlap

ChIP NCI-H128 GSE41105.MAX.NCI-H128 198 bp overlap

ChIP WA01 ENCSR000EUP.MAX.WA01 231 bp overlap

MECOM 1 dataset

ChIP SKH1_CEBPA-ER_E2 GSE102697.MECOM.SKH1_CEBPA-ER_E2 174 bp overlap

MEIS1 2 datasets

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MYB_MA0100.4 6 bp overlap

MYOD1 2 datasets

Motif DE_12h DE_12h-MYOD1_MA0499.3 9 bp overlap

Motif DE_72h DE_72h-MYOD1_MA0499.3 9 bp overlap

Motif DE_72h DE_72h-MZF1_MA0056.3 8 bp overlap

NANOG 2 datasets

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 365 bp overlap

ChIP hESC GSE18292.NANOG.hESC 139 bp overlap

ChIP ProEs GSE59087.NFE2.ProEs 96 bp overlap

Motif DE_72h DE_72h-NFIA_MA0670.2 6 bp overlap

ChIP Ishikawa ENCSR000BUT.NFIC.Ishikawa 160 bp overlap

Motif DE_72h DE_72h-NFIX_MA0671.2 6 bp overlap

ChIP fetal_testis GSE100639.PAX5.fetal_testis 174 bp overlap

ChIP hiPSC GSE125768.PDX1.hiPSC 204 bp overlap

ChIP T-47D_R5020 GSE68355.PGR.T-47D_R5020 170 bp overlap

PKNOX2 2 datasets

Motif DE_12h DE_12h-PKNOX2_MA0783.1 12 bp overlap

Motif DE_72h DE_72h-PKNOX2_MA0783.1 12 bp overlap

POU5F1 1 dataset

ChIP hiPSC GSE56567.POU5F1.hiPSC 220 bp overlap

PRDM15 1 dataset

ChIP WTC11 ENCFF108TMF 372 bp overlap

PRDM9 1 dataset

Motif DE_72h DE_72h-PRDM9_MA1723.2 20 bp overlap

PSIP1 1 dataset

ChIP T-REx-293 GSE117155.PSIP1.T-REx-293 232 bp overlap

Ptf1A 2 datasets

Motif DE_12h DE_12h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_72h DE_72h-Ptf1A_MA1620.2 8 bp overlap

RAD21 2 datasets

ChIP GM12878 ENCFF101UQZ 191 bp overlap

ChIP GM12878 ENCSR000BMY.RAD21.GM12878 127 bp overlap

RBBP5 2 datasets

ChIP WA01 ENCSR000AQC.RBBP5.WA01 174 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 125 bp overlap

ChIP 786-M1A GSE98012.RELA.786-M1A 277 bp overlap

RREB1 1 dataset

Motif DE_72h DE_72h-RREB1_MA0073.2 19 bp overlap

Motif DE_72h DE_72h-Rarb_MA0858.1 17 bp overlap

SAP30 1 dataset

ChIP WA01 ENCSR000ATR.SAP30.WA01 246 bp overlap

SCRT2 1 dataset

ChIP HEK293 ENCFF711QQB 393 bp overlap

SIN3A 5 datasets

ChIP H1 ENCFF042ZSL 472 bp overlap

ChIP H1 ENCFF896IJG 301 bp overlap

ChIP WA01 ENCSR000EBO.SIN3A.WA01 255 bp overlap

ChIP WA01 ENCSR000BIS.SIN3A.WA01 185 bp overlap

ChIP hiPSC_IID12 GSE106870.SIN3A.hiPSC_IID12 195 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 173 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 336 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 434 bp overlap

SMAD2_3 3 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 333 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 251 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 269 bp overlap

SMARCA4 3 datasets

ChIP 501-mel_SHCTR GSE61965.SMARCA4.501-mel_SHCTR 276 bp overlap

ChIP 501-mel_SHCTR GSE61965.SMARCA4.501-mel_SHCTR 375 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 206 bp overlap

SMARCB1 1 dataset

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 220 bp overlap

SMARCC1 2 datasets

ChIP hiPSC GSE124903.SMARCC1.hiPSC 178 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 182 bp overlap

SMC1A 1 dataset

ChIP monocyte_INFg GSE98367.SMC1A.monocyte_INFg 131 bp overlap

SNAI2 2 datasets

Motif DE_12h DE_12h-SNAI2_MA0745.3 8 bp overlap

Motif DE_72h DE_72h-SNAI2_MA0745.3 8 bp overlap

SNAI3 2 datasets

Motif DE_12h DE_12h-SNAI3_MA1559.2 9 bp overlap

Motif DE_72h DE_72h-SNAI3_MA1559.2 9 bp overlap

SOX10 1 dataset

Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 231 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 749 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 178 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 207 bp overlap

SPI1 12 datasets

ChIP CTV-1_FLAG_15perc GSE128835.SPI1.CTV-1_FLAG_15perc 182 bp overlap

ChIP DC_96h_donorM GSE128834.SPI1.DC_96h_donorM 166 bp overlap

ChIP HL-60 ENCFF645GBT 271 bp overlap

ChIP K-562 GSE70482.SPI1.K-562 212 bp overlap

ChIP K-562 ENCSR000BGW.SPI1.K-562 124 bp overlap

ChIP K-562_NABUT GSE74999.SPI1.K-562_NABUT 245 bp overlap

ChIP K562 ENCFF410ORC 205 bp overlap

ChIP OCI-Ly7 GSE69558.SPI1.OCI-Ly7 222 bp overlap

ChIP U-937 GSE128834.SPI1.U-937 188 bp overlap

ChIP monocyte_MACROPHAGE GSE31621.SPI1.monocyte_MACROPHAGE 159 bp overlap

ChIP primary-monocyte_donorA_ncMO GSE128834.SPI1.primary-monocyte_donorA_ncMO 84 bp overlap

ChIP primary-neutrophil_donorF GSE128834.SPI1.primary-neutrophil_donorF 117 bp overlap

SREBP2 2 datasets

ChIP monocyte GSE129202.SREBP2.monocyte 81 bp overlap

ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 334 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 262 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 227 bp overlap

TCF12 3 datasets

ChIP GM12878 ENCSR000BGZ.TCF12.GM12878 97 bp overlap

ChIP H1 ENCFF203EBH 251 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 254 bp overlap

TCF3 2 datasets

ChIP GM12878 ENCSR000BQT.TCF3.GM12878 132 bp overlap

ChIP NPC GSE154479.TCF3.NPC 365 bp overlap

TEAD1 1 dataset

Motif DE_72h DE_72h-TEAD1_MA0090.4 9 bp overlap

TEAD4 1 dataset

Motif DE_72h DE_72h-TEAD4_MA0809.3 8 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 188 bp overlap

Motif DE_72h DE_72h-Vdr_MA0693.4 7 bp overlap

ChIP RS4-11 GSE72864.WDR5.RS4-11 146 bp overlap

ChIP HCT-116 ENCSR000BNX.YY1.HCT-116 102 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 123 bp overlap

ZBTB17 1 dataset

ChIP HEK293 ENCFF865LIO 382 bp overlap

ZBTB2 1 dataset

ChIP GM12878 GSE97661.ZBTB2.GM12878 208 bp overlap

ZBTB6 1 dataset

ChIP HEK293 GSE76494.ZBTB6.HEK293 190 bp overlap

ZBTB7B 1 dataset

Motif DE_72h DE_72h-ZBTB7B_MA0694.2 10 bp overlap

ZEB1 2 datasets

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap

ChIP HEK293 ENCFF033NQQ 363 bp overlap

ZNF136 1 dataset

Motif DE_72h DE_72h-ZNF136_MA1588.1 15 bp overlap

ZNF143 1 dataset

Motif DE_72h DE_72h-ZNF143_MA0088.2 16 bp overlap

ZNF148 1 dataset

ChIP K-562 GSE121133.ZNF148.K-562 329 bp overlap

ZNF257 1 dataset

ChIP HEK293T GSE78099.ZNF257.HEK293T 188 bp overlap

ZNF281 1 dataset

ChIP K-562 GSE121133.ZNF281.K-562 198 bp overlap

ZNF366 1 dataset

ChIP HEK293 ENCSR106EBH.ZNF366.HEK293 252 bp overlap

ZNF423 1 dataset

ChIP WTC11 ENCFF574PBR 275 bp overlap

ZNF449 1 dataset

Motif DE_72h DE_72h-ZNF449_MA1656.2 10 bp overlap

ZNF462 1 dataset

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 142 bp overlap

ZNF574 1 dataset

Motif DE_72h DE_72h-ZNF574_MA1982.2 14 bp overlap

ZNF682 1 dataset

Motif DE_72h DE_72h-ZNF682_MA1599.2 11 bp overlap

ZNF708 1 dataset

Motif DE_72h DE_72h-ZNF708_MA1730.2 9 bp overlap

ZNF75A 1 dataset

Motif DE_72h DE_72h-ZNF75A_MA2097.1 12 bp overlap

ZSCAN21 1 dataset

ChIP HEK293 ENCSR253CKN.ZSCAN21.HEK293 260 bp overlap

Zic1::Zic2 1 dataset

Motif DE_72h DE_72h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap

Motif DE_72h DE_72h-Zic3_MA0697.3 7 bp overlap