Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:120,290,301–120,293,526 | 288.2 kb | Distal (>10kb) Multiome | 1338 | |
| chr12:120,302,138–120,302,609 | 279.1 kb | Distal (>10kb) Multiome | 711 | |
| chr12:120,317,215–120,317,997 | 263.7 kb | Distal (>10kb) Multiome | 872 | |
| chr12:120,361,277–120,362,299 | 219.6 kb | Distal (>10kb) Multiome | 308 | |
| chr12:120,368,637–120,370,303 | 212.2 kb | Distal (>10kb) Multiome | 250 | |
| chr12:120,388,762–120,389,560 | 192.2 kb | Distal (>10kb) Multiome | 178 | |
| chr12:120,394,470–120,395,052 | 186.6 kb | Distal (>10kb) Multiome | 283 | |
| chr12:120,413,842–120,414,516 | 167.2 kb | Distal (>10kb) Multiome | 289 | |
| chr12:120,437,436–120,438,568 | 143.4 kb | Distal (>10kb) Multiome | 725 | |
| chr12:120,445,927–120,446,970 | 134.9 kb | Distal (>10kb) Multiome | 982 | |
| chr12:120,468,864–120,470,390 | 111.6 kb | Distal (>10kb) Multiome | 942 | |
| chr12:120,495,362–120,496,939 | 85.4 kb | Distal (>10kb) Multiome | 794 | |
| chr12:120,528,856–120,529,468 | 52.2 kb | Distal (>10kb) Multiome | 849 | |
| chr12:120,534,230–120,535,077 | 46.9 kb | Distal (>10kb) Multiome | 730 | |
| chr12:120,580,919–120,581,830 | 52 bp | At TSS Multiome | 736 | |
| chr12:120,583,463–120,583,674 | 2.1 kb | Proximal (<10kb) | 281 | |
| chr12:120,584,329–120,585,045 | 3.4 kb | Proximal (<10kb) Multiome | 460 | |
| chr12:120,640,005–120,641,704 | 59.1 kb | Distal (>10kb) Multiome HiCAR | 562 | |
| chr12:120,648,914–120,649,665 | 67.9 kb | Distal (>10kb) Multiome HiCAR | 405 | |
| chr12:120,668,575–120,669,135 | 87.5 kb | Distal (>10kb) Multiome | 98 | |
| chr12:120,686,185–120,687,741 | 105.4 kb | Distal (>10kb) Multiome HiCAR | 1030 | |
| chr12:120,710,025–120,711,277 | 129.0 kb | Distal (>10kb) Multiome HiCAR | 573 | |
| chr12:120,725,271–120,726,309 | 144.4 kb | Distal (>10kb) Multiome | 663 | |
| chr12:120,822,842–120,823,717 | 241.8 kb | Distal (>10kb) Multiome | 117 | |
| chr12:121,016,022–121,016,705 | 435.1 kb | Distal (>10kb) Multiome HiCAR | 674 |
Genomic view of the POP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.