ZBTB17

zinc finger and BTB domain containing 17 | MIZ1, pHZ-67, ZNF151, ZNF60

This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

Biological processes 25 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)G1 to G0 transition (GO:0070314)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)core promoter sequence-specific DNA binding (GO:0001046)negative regulation of cell cycle (GO:0045786)negative regulation of cell population proliferation (GO:0008285)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein-DNA complex (GO:0032993)protein-containing complex (GO:0032991)regulation of cytokine production (GO:0001817)regulation of immune system process (GO:0002682)transcription coactivator binding (GO:0001223)

Expression (TPM)

TFs regulating ZBTB17 0 TFs

Transcription factors with Perturb-seq knockdown data for ZBTB17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZBTB17

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:15,676,618–15,677,408	298.9 kb	Distal (>10kb) Multiome	95
chr1:15,741,258–15,741,859	234.6 kb	Distal (>10kb) Multiome	436
chr1:15,757,615–15,759,609	217.5 kb	Distal (>10kb) Multiome	439
chr1:15,799,931–15,800,776	175.8 kb	Distal (>10kb) Multiome	734
chr1:15,834,229–15,836,682	140.0 kb	Distal (>10kb) Multiome	1154
chr1:15,847,036–15,848,900	128.4 kb	Distal (>10kb) Multiome	817
chr1:15,849,314–15,850,241	126.4 kb	Distal (>10kb) Multiome	788
chr1:15,975,319–15,976,269	192 bp	At TSS Multiome	788
chr1:16,012,632–16,013,679	37.1 kb	Distal (>10kb) Multiome	615
chr1:16,026,326–16,027,360	50.8 kb	Distal (>10kb) Multiome	186
chr1:16,032,851–16,033,317	56.9 kb	Distal (>10kb) Multiome	349
chr1:16,048,527–16,049,209	72.6 kb	Distal (>10kb) Multiome	288
chr1:16,073,117–16,073,908	97.5 kb	Distal (>10kb) Multiome	375
chr1:16,115,357–16,116,733	140.0 kb	Distal (>10kb) Multiome	269
chr1:16,145,972–16,147,046	170.4 kb	Distal (>10kb) Multiome	689
chr1:16,154,818–16,156,461	180.0 kb	Distal (>10kb) Multiome	742
chr1:16,167,178–16,168,479	191.8 kb	Distal (>10kb) Multiome	501
chr1:16,206,128–16,208,181	230.7 kb	Distal (>10kb) Multiome	760
chr1:16,212,441–16,212,918	236.6 kb	Distal (>10kb) Multiome	183
chr1:16,215,805–16,218,073	241.5 kb	Distal (>10kb) Multiome	490
chr1:16,226,476–16,227,566	250.9 kb	Distal (>10kb) Multiome	208
chr1:16,236,291–16,237,528	261.1 kb	Distal (>10kb) Multiome	717

Genome Browser

Genomic view of the ZBTB17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.