The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:120,265,150–120,266,362 | 268.5 kb | Distal (>10kb) Multiome | 617 | |
| chr12:120,290,301–120,293,526 | 241.2 kb | Distal (>10kb) Multiome | 1338 | |
| chr12:120,302,138–120,302,609 | 232.0 kb | Distal (>10kb) Multiome | 711 | |
| chr12:120,317,215–120,317,997 | 216.7 kb | Distal (>10kb) Multiome | 872 | |
| chr12:120,361,277–120,362,299 | 172.6 kb | Distal (>10kb) Multiome | 308 | |
| chr12:120,368,637–120,370,303 | 165.2 kb | Distal (>10kb) Multiome | 250 | |
| chr12:120,388,762–120,389,560 | 145.1 kb | Distal (>10kb) Multiome | 178 | |
| chr12:120,394,470–120,395,052 | 139.6 kb | Distal (>10kb) Multiome | 283 | |
| chr12:120,413,842–120,414,516 | 120.2 kb | Distal (>10kb) Multiome | 289 | |
| chr12:120,437,436–120,438,568 | 96.3 kb | Distal (>10kb) Multiome | 725 | |
| chr12:120,445,927–120,446,970 | 87.9 kb | Distal (>10kb) Multiome | 982 | |
| chr12:120,468,864–120,470,390 | 64.6 kb | Distal (>10kb) Multiome | 942 | |
| chr12:120,495,362–120,496,939 | 38.3 kb | Distal (>10kb) Multiome | 794 | |
| chr12:120,528,856–120,529,468 | 5.2 kb | Proximal (<10kb) Multiome | 849 | |
| chr12:120,534,230–120,535,077 | 144 bp | At TSS Multiome | 730 | |
| chr12:120,580,919–120,581,830 | 47.1 kb | Distal (>10kb) Multiome | 736 | |
| chr12:120,584,329–120,585,045 | 50.4 kb | Distal (>10kb) Multiome | 460 | |
| chr12:120,640,005–120,641,704 | 106.1 kb | Distal (>10kb) Multiome | 562 | |
| chr12:120,648,914–120,649,665 | 115.0 kb | Distal (>10kb) Multiome | 405 | |
| chr12:120,668,575–120,669,135 | 134.5 kb | Distal (>10kb) Multiome | 98 | |
| chr12:120,686,185–120,687,741 | 152.4 kb | Distal (>10kb) Multiome | 1030 | |
| chr12:120,710,025–120,711,277 | 176.0 kb | Distal (>10kb) Multiome | 573 | |
| chr12:120,725,271–120,726,309 | 191.5 kb | Distal (>10kb) Multiome | 663 | |
| chr12:120,822,842–120,823,717 | 288.8 kb | Distal (>10kb) Multiome | 117 |
Genomic view of the RNF10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.