Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription coactivator activity. Involved in mRNA 5'-splice site recognition and positive regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear periphery; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PSIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:15,249,131–15,250,215 | 261.4 kb | Distal (>10kb) Multiome | 244 | |
| chr9:15,306,092–15,307,952 | 203.7 kb | Distal (>10kb) Multiome | 885 | |
| chr9:15,354,632–15,356,131 | 156.0 kb | Distal (>10kb) Multiome | 170 | |
| chr9:15,422,127–15,423,372 | 88.3 kb | Distal (>10kb) Multiome | 914 | |
| chr9:15,510,031–15,511,595 | 59 bp | At TSS Multiome | 913 | |
| chr9:15,512,558–15,513,923 | 2.4 kb | Proximal (<10kb) Multiome | 289 | |
| chr9:15,529,900–15,530,578 | 19.3 kb | Distal (>10kb) Multiome | 210 | |
| chr9:15,551,866–15,553,797 | 42.1 kb | Distal (>10kb) Multiome | 898 |
Genomic view of the PSIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.