Predicted to be involved in Spemann organizer formation and negative regulation of Wnt signaling pathway. Predicted to be located in nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C12orf43. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C12orf43 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C12orf43, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:120,580,919–120,581,830 | 435.1 kb | Distal (>10kb) Multiome HiCAR | 736 | |
| chr12:120,584,329–120,585,045 | 431.7 kb | Distal (>10kb) Multiome HiCAR | 460 | |
| chr12:120,686,185–120,687,741 | 329.7 kb | Distal (>10kb) Multiome HiCAR | 1030 | |
| chr12:120,710,025–120,711,277 | 306.1 kb | Distal (>10kb) Multiome HiCAR | 573 | |
| chr12:120,725,271–120,726,309 | 290.7 kb | Distal (>10kb) Multiome | 663 | |
| chr12:120,822,842–120,823,717 | 193.3 kb | Distal (>10kb) Multiome | 117 | |
| chr12:120,903,538–120,904,786 | 112.1 kb | Distal (>10kb) Multiome | 749 | |
| chr12:121,016,022–121,016,705 | at TSS | At TSS Multiome | 674 | |
| chr12:121,026,128–121,026,637 | 9.9 kb | Proximal (<10kb) Multiome HiCAR | 253 | |
| chr12:121,209,800–121,210,863 | 193.7 kb | Distal (>10kb) Multiome | 894 | |
| chr12:121,230,137–121,230,781 | 214.0 kb | Distal (>10kb) Multiome | 326 | |
| chr12:121,280,329–121,281,482 | 264.4 kb | Distal (>10kb) Multiome | 112 | |
| chr12:121,295,441–121,297,879 | 280.4 kb | Distal (>10kb) Multiome | 801 |
Genomic view of the C12orf43 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.