Enables 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity. Involved in methylation and ubiquinone biosynthetic process. Located in mitochondrial inner membrane and mitochondrial matrix. Part of ubiquinone biosynthesis complex. Implicated in primary coenzyme Q10 deficiency 9. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COQ5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COQ5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COQ5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:120,228,170–120,231,900 | 298.4 kb | Distal (>10kb) Multiome | 1050 | |
| chr12:120,265,150–120,266,362 | 263.3 kb | Distal (>10kb) Multiome | 617 | |
| chr12:120,290,301–120,293,526 | 236.0 kb | Distal (>10kb) Multiome | 1338 | |
| chr12:120,302,138–120,302,609 | 226.8 kb | Distal (>10kb) Multiome | 711 | |
| chr12:120,317,215–120,317,997 | 211.5 kb | Distal (>10kb) Multiome | 872 | |
| chr12:120,361,277–120,362,299 | 167.4 kb | Distal (>10kb) Multiome | 308 | |
| chr12:120,368,637–120,370,303 | 159.9 kb | Distal (>10kb) Multiome | 250 | |
| chr12:120,388,762–120,389,560 | 139.9 kb | Distal (>10kb) Multiome | 178 | |
| chr12:120,394,470–120,395,052 | 134.4 kb | Distal (>10kb) Multiome | 283 | |
| chr12:120,413,842–120,414,516 | 115.0 kb | Distal (>10kb) Multiome | 289 | |
| chr12:120,437,436–120,438,568 | 91.1 kb | Distal (>10kb) Multiome | 725 | |
| chr12:120,445,927–120,446,970 | 82.7 kb | Distal (>10kb) Multiome | 982 | |
| chr12:120,468,864–120,470,390 | 59.4 kb | Distal (>10kb) Multiome | 942 | |
| chr12:120,495,362–120,496,939 | 33.1 kb | Distal (>10kb) Multiome HiCAR | 794 | |
| chr12:120,528,856–120,529,468 | 11 bp | At TSS Multiome | 849 | |
| chr12:120,534,230–120,535,077 | 5.3 kb | Proximal (<10kb) Multiome | 730 | |
| chr12:120,580,919–120,581,830 | 52.3 kb | Distal (>10kb) Multiome | 736 | |
| chr12:120,584,329–120,585,045 | 55.6 kb | Distal (>10kb) Multiome | 460 | |
| chr12:120,640,005–120,641,704 | 111.3 kb | Distal (>10kb) Multiome | 562 | |
| chr12:120,648,914–120,649,665 | 120.2 kb | Distal (>10kb) Multiome | 405 | |
| chr12:120,668,575–120,669,135 | 139.7 kb | Distal (>10kb) Multiome | 98 | |
| chr12:120,686,185–120,687,741 | 157.6 kb | Distal (>10kb) Multiome | 1030 | |
| chr12:120,710,025–120,711,277 | 181.2 kb | Distal (>10kb) Multiome | 573 | |
| chr12:120,725,271–120,726,309 | 196.7 kb | Distal (>10kb) Multiome | 663 | |
| chr12:120,822,842–120,823,717 | 294.0 kb | Distal (>10kb) Multiome | 117 |
Genomic view of the COQ5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.