chr16:67,915,108–67,915,887

chr16 : 67,915,108 – 67,915,887

779 bp 92 TFs 13 linked genes

This 779 bp open chromatin element is linked to 13 target genes and is bound by 92 transcription factors.

Linked Genes

13 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PSKH1		22.2 kb	Distal	Multiome
EDC4		42.4 kb	Distal	Multiome
SLC12A4		53.2 kb	Distal	Multiome
DPEP3		65.1 kb	Distal	Multiome
NUTF2		68.5 kb	Distal	Multiome
THAP11		73.1 kb	Distal	Multiome
CENPT		81.5 kb	Distal	Multiome
DDX28		107.8 kb	Distal	Multiome
DUS2		107.9 kb	Distal	Multiome
RANBP10		108.9 kb	Distal	Multiome
NFATC3		169.9 kb	Distal	Multiome
GFOD2		196.1 kb	Distal	Multiome
ACD		255.1 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

92 transcription factors

ChIP LNCaP_SHGATA2_R1881 GSE69043.AR.LNCaP_SHGATA2_R1881 181 bp overlap

ARID1A 2 datasets

ChIP MCF-7_DCDT GSE123284.ARID1A.MCF-7_DCDT 363 bp overlap

ChIP MCF-7_Fulvestrant GSE123284.ARID1A.MCF-7_Fulvestrant 285 bp overlap

CHD2 2 datasets

ChIP SK-N-SH ENCFF669KMB 361 bp overlap

ChIP SK-N-SH ENCSR274SLQ.CHD2.SK-N-SH 170 bp overlap

CREBBP 1 dataset

ChIP MCF-7 ERP000901.CREBBP.MCF-7 181 bp overlap

Cebpa 3 datasets

ChIP BLaER1 ENCFF364PUR 71 bp overlap

ChIP BLaER1 ENCFF460KDD 251 bp overlap

ChIP BLaER1 ENCFF460KDD 251 bp overlap

DNMT3B 1 dataset

ChIP HUES-8 GSE99346.DNMT3B.HUES-8 111 bp overlap

Motif DE_24h DE_24h-Dux_MA0611.3 11 bp overlap

Motif DE_36h DE_36h-Dux_MA0611.3 11 bp overlap

ChIP GM12878 ENCSR439WAF.E4F1.GM12878 232 bp overlap

Motif DE_24h DE_24h-EHF_MA0598.4 9 bp overlap

Motif DE_36h DE_36h-EHF_MA0598.4 9 bp overlap

ELF1 2 datasets

Motif DE_24h DE_24h-ELF1_MA0473.4 9 bp overlap

Motif DE_36h DE_36h-ELF1_MA0473.4 9 bp overlap

ELF3 2 datasets

Motif DE_24h DE_24h-ELF3_MA0640.3 9 bp overlap

Motif DE_36h DE_36h-ELF3_MA0640.3 9 bp overlap

ELK4 2 datasets

Motif DE_24h DE_24h-ELK4_MA0076.3 9 bp overlap

Motif DE_36h DE_36h-ELK4_MA0076.3 9 bp overlap

EP300 1 dataset

ChIP SK-N-SH ENCSR000EHV.EP300.SK-N-SH 281 bp overlap

ESR1 10 datasets

ChIP MCF-7 GSE117492.ESR1.MCF-7 403 bp overlap

ChIP MCF-7 GSE128445.ESR1.MCF-7 302 bp overlap

ChIP MCF-7_DMSO GSE125594.ESR1.MCF-7_DMSO 254 bp overlap

ChIP MCF-7_E2 ERP000209.ESR1.MCF-7_E2 129 bp overlap

ChIP MCF-7_IL1b_45m GSE67295.ESR1.MCF-7_IL1b_45m 160 bp overlap

ChIP MCF-7_jc5850 GSE126004.ESR1.MCF-7_jc5850 213 bp overlap

ChIP MCF-7_jc5856 GSE126004.ESR1.MCF-7_jc5856 211 bp overlap

ChIP SUM44PE_ESR1_wildtype GSE100074.ESR1.SUM44PE_ESR1_wildtype 273 bp overlap

ChIP T-47D_siFOXA1-IL6 GSE126004.ESR1.T-47D_siFOXA1-IL6 257 bp overlap

ChIP T-47D_siFOXA1-Veh GSE126004.ESR1.T-47D_siFOXA1-Veh 177 bp overlap

ETV1 2 datasets

Motif DE_24h DE_24h-ETV1_MA0761.3 9 bp overlap

Motif DE_36h DE_36h-ETV1_MA0761.3 9 bp overlap

ChIP T-47D GSE129803.ETV4.T-47D 289 bp overlap

Motif DE_24h DE_24h-Erg_MA0474.4 10 bp overlap

Motif DE_36h DE_36h-Erg_MA0474.4 10 bp overlap

GABPA 2 datasets

Motif DE_24h DE_24h-GABPA_MA0062.4 10 bp overlap

Motif DE_36h DE_36h-GABPA_MA0062.4 10 bp overlap

GATA2 7 datasets

ChIP LNCaP_CSFCS GSE69043.GATA2.LNCaP_CSFCS 178 bp overlap

ChIP LNCaP_FBS GSE69043.GATA2.LNCaP_FBS 141 bp overlap

ChIP SH-SY5Y ENCFF485YIB 322 bp overlap

ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 400 bp overlap

ChIP SK-N-SH ENCFF764OZD 417 bp overlap

ChIP SK-N-SH ENCSR706VOO.GATA2.SK-N-SH 316 bp overlap

ChIP hiPSC_SLC6ebs GSE107639.GATA2.hiPSC_SLC6ebs 182 bp overlap

GATA3 15 datasets

ChIP CLB-Ga GSE90683.GATA3.CLB-Ga 225 bp overlap

ChIP Kelly GSE65664.GATA3.Kelly 213 bp overlap

ChIP MCF-7 ENCFF437NQS 371 bp overlap

ChIP MCF-7 GSE51274.GATA3.MCF-7 388 bp overlap

ChIP MCF-7 GSE128445.GATA3.MCF-7 282 bp overlap

ChIP MCF-7 GSE117492.GATA3.MCF-7 184 bp overlap

ChIP MCF-7_DMSO GSE29073.GATA3.MCF-7_DMSO 128 bp overlap

ChIP MCF-7_E2 GSE81510.GATA3.MCF-7_E2 319 bp overlap

ChIP MCF-7_E2 GSE60270.GATA3.MCF-7_E2 224 bp overlap

ChIP MCF-7_E2 GSE29073.GATA3.MCF-7_E2 153 bp overlap

ChIP MCF-7_E2_Dex GSE81510.GATA3.MCF-7_E2_Dex 168 bp overlap

ChIP MCF-7_ICI GSE81510.GATA3.MCF-7_ICI 140 bp overlap

ChIP MCF-7_sgScr GSE133072.GATA3.MCF-7_sgScr 211 bp overlap

ChIP SH-SY5Y GSE65664.GATA3.SH-SY5Y 179 bp overlap

ChIP T-47D ENCSR000BMX.GATA3.T-47D 207 bp overlap

GATA3_Nter 1 dataset

ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 264 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-2 367 bp overlap

Motif DE_24h DE_24h-GATA4_MA0482.3 8 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

GATA5 2 datasets

Motif DE_24h DE_24h-GATA5_MA0766.3 8 bp overlap

Motif DE_36h DE_36h-GATA5_MA0766.3 8 bp overlap

GATA6 7 datasets

ChIP DE DE-GATA6-2 331 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 604 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 597 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 690 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 553 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 681 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 653 bp overlap

GFI1B 1 dataset

ChIP K-562 ENCSR509GDT.GFI1B.K-562 186 bp overlap

GRHL2 1 dataset

ChIP MCF-7-WS8_VEH GSE113092.GRHL2.MCF-7-WS8_VEH 291 bp overlap

HAND2 2 datasets

ChIP Kelly GSE94822.HAND2.Kelly 171 bp overlap

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 184 bp overlap

HDAC2 2 datasets

ChIP K-562 ENCSR893WSB.HDAC2.K-562 282 bp overlap

ChIP K-562 ENCSR000BMG.HDAC2.K-562 138 bp overlap

HNF4A 1 dataset

ChIP liver ERP002306.HNF4A.liver 85 bp overlap

HNF4G 1 dataset

ChIP liver ENCFF170YNZ 56 bp overlap

INSM1 4 datasets

Motif DE_24h DE_24h-INSM1_MA0155.1 12 bp overlap

Motif DE_24h DE_24h-INSM1_MA0155.1 12 bp overlap

Motif DE_36h DE_36h-INSM1_MA0155.1 12 bp overlap

Motif DE_36h DE_36h-INSM1_MA0155.1 12 bp overlap

Ikzf3 2 datasets

Motif DE_24h DE_24h-Ikzf3_MA1992.2 9 bp overlap

Motif DE_36h DE_36h-Ikzf3_MA1992.2 9 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 320 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 399 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 485 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 434 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 428 bp overlap

KDM1A 1 dataset

ChIP SH-SY5Y_B3 GSE58258.KDM1A.SH-SY5Y_B3 434 bp overlap

KLF10 2 datasets

Motif DE_24h DE_24h-KLF10_MA1511.2 9 bp overlap

Motif DE_36h DE_36h-KLF10_MA1511.2 9 bp overlap

KLF12 2 datasets

Motif DE_24h DE_24h-KLF12_MA0742.2 9 bp overlap

Motif DE_36h DE_36h-KLF12_MA0742.2 9 bp overlap

KLF14 2 datasets

Motif DE_24h DE_24h-KLF14_MA0740.2 9 bp overlap

Motif DE_36h DE_36h-KLF14_MA0740.2 9 bp overlap

KLF16 2 datasets

Motif DE_24h DE_24h-KLF16_MA0741.1 11 bp overlap

Motif DE_36h DE_36h-KLF16_MA0741.1 11 bp overlap

KLF5 2 datasets

Motif DE_24h DE_24h-KLF5_MA0599.1 10 bp overlap

Motif DE_36h DE_36h-KLF5_MA0599.1 10 bp overlap

ChIP liver ENCFF092GVW 146 bp overlap

Motif DE_24h DE_24h-MAZ_MA1522.2 8 bp overlap

Motif DE_36h DE_36h-MAZ_MA1522.2 8 bp overlap

MEIS1 1 dataset

ChIP HepG2 ENCFF706DID 66 bp overlap

ChIP SK-N-SH ENCFF746HVJ 153 bp overlap

ChIP LNCaP GSE117430.MYC.LNCaP 66 bp overlap

NANOG 1 dataset

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 479 bp overlap

ChIP HepG2 ENCFF815HWK 94 bp overlap

NR2F2 1 dataset

ChIP K-562 ENCSR000BRS.NR2F2.K-562 126 bp overlap

PATZ1 2 datasets

Motif DE_24h DE_24h-PATZ1_MA1961.2 11 bp overlap

Motif DE_36h DE_36h-PATZ1_MA1961.2 11 bp overlap

ChIP MCF-7_PROG GSE68355.PGR.MCF-7_PROG 230 bp overlap

PHOX2B 2 datasets

Motif DE_24h DE_24h-PHOX2B_MA0681.3 12 bp overlap

Motif DE_36h DE_36h-PHOX2B_MA0681.3 12 bp overlap

PITX3 1 dataset

ChIP SH-SY5Y GSE93275.PITX3.SH-SY5Y 277 bp overlap

POU5F1 1 dataset

ChIP DE_D1 DED1-OCT4_Batch_II 635 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 278 bp overlap

PRDM1 2 datasets

ChIP HEK293 ENCFF302TBP 253 bp overlap

ChIP HEK293 GSE76494.PRDM1.HEK293 152 bp overlap

RAD21 1 dataset

ChIP liver ENCFF522JHE 88 bp overlap

RCOR1 2 datasets

ChIP SK-N-SH ENCFF518EXB 144 bp overlap

ChIP SK-N-SH ENCSR009TKN.RCOR1.SK-N-SH 276 bp overlap

RXRA 2 datasets

ChIP liver ENCFF077DAP 219 bp overlap

ChIP liver ENCFF077DAP 117 bp overlap

Rarg 2 datasets

Motif DE_24h DE_24h-Rarg_MA0860.1 17 bp overlap

Motif DE_36h DE_36h-Rarg_MA0860.1 17 bp overlap

SCRT1 2 datasets

ChIP HEK293 ENCFF513YVP 417 bp overlap

ChIP HEK293 ENCSR605MGM.SCRT1.HEK293 323 bp overlap

SCRT2 1 dataset

ChIP HEK293 ENCFF711QQB 394 bp overlap

SMAD1 1 dataset

ChIP HepG2 ENCFF892OZT 597 bp overlap

SMAD2 3 datasets

Motif DE_24h DE_24h-SMAD2_MA1964.2 6 bp overlap

Motif DE_36h DE_36h-SMAD2_MA1964.2 6 bp overlap

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 636 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 606 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 779 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 779 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 718 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 779 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 734 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 702 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 779 bp overlap

SMAD3 1 dataset

ChIP BG03_DIFF_2H GSE36578.SMAD3.BG03_DIFF_2H 176 bp overlap

SMARCA4 1 dataset

ChIP MCF-7 GSE123284.SMARCA4.MCF-7 301 bp overlap

SMARCB1 3 datasets

ChIP MCF-7_4-hydroxytamoxifen GSE123284.SMARCB1.MCF-7_4-hydroxytamoxifen 296 bp overlap

ChIP MCF-7_DCDT GSE123284.SMARCB1.MCF-7_DCDT 428 bp overlap

ChIP MCF-7_estrogen GSE123284.SMARCB1.MCF-7_estrogen 307 bp overlap

SMARCC1 1 dataset

ChIP DE_D1 S10-DE-d1-BAF155-exp1 254 bp overlap

Motif DE_24h DE_24h-SP1_MA0079.5 9 bp overlap

Motif DE_36h DE_36h-SP1_MA0079.5 9 bp overlap

ChIP liver ENCFF769YSM 165 bp overlap

ChIP liver ENCFF769YSM 131 bp overlap

Motif DE_24h DE_24h-SP2_MA0516.3 9 bp overlap

Motif DE_36h DE_36h-SP2_MA0516.3 9 bp overlap

Motif DE_24h DE_24h-SP3_MA0746.3 11 bp overlap

Motif DE_36h DE_36h-SP3_MA0746.3 11 bp overlap

Motif DE_24h DE_24h-SP4_MA0685.2 9 bp overlap

Motif DE_36h DE_36h-SP4_MA0685.2 9 bp overlap

Motif DE_24h DE_24h-SP5_MA1965.2 6 bp overlap

Motif DE_36h DE_36h-SP5_MA1965.2 6 bp overlap

Motif DE_36h DE_36h-SP5_MA1965.2 6 bp overlap

Motif DE_24h DE_24h-SP8_MA0747.2 11 bp overlap

Motif DE_36h DE_36h-SP8_MA0747.2 11 bp overlap

STAT3 1 dataset

ChIP T-47D_JC5056 GSE126004.STAT3.T-47D_JC5056 273 bp overlap

TEAD4 1 dataset

ChIP BJ_fibroblast_CD13-neg GSE114367.TEAD4.BJ_fibroblast_CD13-neg 371 bp overlap

TFAP2B 1 dataset

ChIP SK-N-SH ENCFF869XXQ 316 bp overlap

TFAP2C 2 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 476 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 472 bp overlap

TSHZ2 1 dataset

ChIP SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour ENCSR282NLQ.TSHZ2.SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour 201 bp overlap

TWIST1 2 datasets

ChIP BE2C GSE80151.TWIST1.BE2C 210 bp overlap

ChIP SK-N-BE2-C GSE80151.TWIST1.SK-N-BE2-C 210 bp overlap

Motif DE_24h DE_24h-Wt1_MA1627.2 10 bp overlap

Motif DE_36h DE_36h-Wt1_MA1627.2 10 bp overlap

ZFP91 2 datasets

ChIP K-562 ENCSR898XMH.ZFP91.K-562 315 bp overlap

ChIP K562 ENCFF501CDP 324 bp overlap

ChIP HepG2 ENCFF016NZF 193 bp overlap

ZIC1 2 datasets

Motif DE_24h DE_24h-ZIC1_MA0696.1 14 bp overlap

Motif DE_36h DE_36h-ZIC1_MA0696.1 14 bp overlap

ZIC4 2 datasets

Motif DE_24h DE_24h-ZIC4_MA0751.2 14 bp overlap

Motif DE_36h DE_36h-ZIC4_MA0751.2 14 bp overlap

ZNF148 2 datasets

Motif DE_24h DE_24h-ZNF148_MA1653.2 10 bp overlap

Motif DE_36h DE_36h-ZNF148_MA1653.2 10 bp overlap

ZNF24 13 datasets

ChIP Hep-G2 ENCSR791AGT.ZNF24.Hep-G2 215 bp overlap

ChIP Hep-G2 ENCSR362NWP.ZNF24.Hep-G2 200 bp overlap

ChIP HepG2 ENCFF357JVV 92 bp overlap

ChIP HepG2 ENCFF361LZL 277 bp overlap

ChIP K-562 ENCSR099NCH.ZNF24.K-562 396 bp overlap

ChIP K-562 ENCSR695EQB.ZNF24.K-562 407 bp overlap

ChIP K-562 ENCSR385AHH.ZNF24.K-562 299 bp overlap

ChIP K-562 ENCSR117WTM.ZNF24.K-562 261 bp overlap

ChIP K562 ENCFF497GLV 295 bp overlap

ChIP K562 ENCFF615YYW 391 bp overlap

ChIP K562 ENCFF781QQQ 244 bp overlap

ChIP K562 ENCFF877JCX 324 bp overlap

ChIP MCF-7 ENCSR503VTG.ZNF24.MCF-7 201 bp overlap

ZNF281 2 datasets

Motif DE_24h DE_24h-ZNF281_MA1630.3 10 bp overlap

Motif DE_36h DE_36h-ZNF281_MA1630.3 10 bp overlap

ZNF865 1 dataset

ChIP HepG2 ENCFF472KAQ 200 bp overlap

ZSCAN4 2 datasets

ChIP HEK293 ENCFF381BKT 323 bp overlap

ChIP HEK293 ENCSR211GNP.ZSCAN4.HEK293 261 bp overlap

Zfp335 2 datasets

Motif DE_24h DE_24h-Zfp335_MA2002.2 7 bp overlap

Motif DE_36h DE_36h-Zfp335_MA2002.2 7 bp overlap

Zic2 2 datasets

Motif DE_24h DE_24h-Zic2_MA1629.2 9 bp overlap

Motif DE_36h DE_36h-Zic2_MA1629.2 9 bp overlap