This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DPEP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPEP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPEP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,718,772–67,720,138 | 261.2 kb | Distal (>10kb) Multiome | 866 | |
| chr16:67,806,066–67,807,386 | 173.8 kb | Distal (>10kb) Multiome | 914 | |
| chr16:67,816,404–67,816,888 | 163.8 kb | Distal (>10kb) Multiome | 690 | |
| chr16:67,833,426–67,834,269 | 146.6 kb | Distal (>10kb) Multiome | 838 | |
| chr16:67,841,337–67,843,276 | 138.4 kb | Distal (>10kb) Multiome | 927 | |
| chr16:67,846,090–67,847,897 | 133.8 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:67,872,739–67,873,665 | 107.4 kb | Distal (>10kb) Multiome | 982 | |
| chr16:67,884,566–67,885,097 | 95.6 kb | Distal (>10kb) Multiome | 264 | |
| chr16:67,892,898–67,893,885 | 87.3 kb | Distal (>10kb) Multiome | 867 | |
| chr16:67,915,108–67,915,887 | 65.1 kb | Distal (>10kb) Multiome | 92 | |
| chr16:67,935,189–67,936,596 | 44.7 kb | Distal (>10kb) Multiome | 980 | |
| chr16:67,963,746–67,964,209 | 16.6 kb | Distal (>10kb) Multiome | 161 | |
| chr16:67,968,087–67,969,341 | 11.8 kb | Distal (>10kb) Multiome | 861 | |
| chr16:67,980,398–67,980,679 | at TSS | At TSS | 128 | |
| chr16:67,993,130–67,993,736 | 12.9 kb | Distal (>10kb) Multiome | 790 | |
| chr16:68,019,222–68,020,043 | 38.9 kb | Distal (>10kb) Multiome | 108 | |
| chr16:68,022,490–68,023,556 | 42.7 kb | Distal (>10kb) Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 104.7 kb | Distal (>10kb) Multiome | 1092 | |
| chr16:68,235,016–68,238,254 | 255.6 kb | Distal (>10kb) Multiome | 1055 | |
| chr16:68,239,582–68,240,355 | 259.5 kb | Distal (>10kb) Multiome | 223 | |
| chr16:68,244,730–68,245,757 | 264.8 kb | Distal (>10kb) Multiome | 803 | |
| chr16:68,264,033–68,265,087 | 284.0 kb | Distal (>10kb) Multiome | 876 |
Genomic view of the DPEP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.