Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EDC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EDC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EDC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,644,719–67,645,304 | 228.1 kb | Distal (>10kb) Multiome | 638 | |
| chr16:67,649,353–67,649,999 | 223.3 kb | Distal (>10kb) Multiome | 112 | |
| chr16:67,652,610–67,653,810 | 220.1 kb | Distal (>10kb) Multiome | 498 | |
| chr16:67,659,631–67,661,707 | 212.2 kb | Distal (>10kb) Multiome | 962 | |
| chr16:67,666,180–67,667,235 | 206.4 kb | Distal (>10kb) Multiome | 713 | |
| chr16:67,667,674–67,668,349 | 205.0 kb | Distal (>10kb) Multiome | 628 | |
| chr16:67,718,772–67,720,138 | 153.7 kb | Distal (>10kb) Multiome | 866 | |
| chr16:67,806,066–67,807,386 | 66.3 kb | Distal (>10kb) Multiome | 914 | |
| chr16:67,816,404–67,816,888 | 56.3 kb | Distal (>10kb) Multiome | 690 | |
| chr16:67,833,426–67,834,269 | 39.2 kb | Distal (>10kb) Multiome | 838 | |
| chr16:67,841,337–67,843,276 | 30.9 kb | Distal (>10kb) Multiome | 927 | |
| chr16:67,846,090–67,847,897 | 26.3 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:67,872,739–67,873,665 | 11 bp | At TSS Multiome | 982 | |
| chr16:67,884,566–67,885,097 | 11.8 kb | Distal (>10kb) Multiome | 264 | |
| chr16:67,892,898–67,893,885 | 20.1 kb | Distal (>10kb) Multiome | 867 | |
| chr16:67,915,108–67,915,887 | 42.4 kb | Distal (>10kb) Multiome | 92 | |
| chr16:67,935,189–67,936,596 | 62.8 kb | Distal (>10kb) Multiome HiCAR | 980 | |
| chr16:67,963,746–67,964,209 | 90.9 kb | Distal (>10kb) Multiome | 161 | |
| chr16:67,968,087–67,969,341 | 95.6 kb | Distal (>10kb) Multiome | 861 | |
| chr16:67,993,130–67,993,736 | 120.4 kb | Distal (>10kb) Multiome | 790 | |
| chr16:68,019,222–68,020,043 | 146.4 kb | Distal (>10kb) Multiome | 108 | |
| chr16:68,022,490–68,023,556 | 150.2 kb | Distal (>10kb) Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 212.2 kb | Distal (>10kb) Multiome | 1092 |
Genomic view of the EDC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.