NUTF2

nuclear transport factor 2 | NTF2, PP15

This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]

Member of: DE-1 DE-1.55

Biological processes 22 terms

cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)identical protein binding (GO:0042802)nuclear import signal receptor activity (GO:0061608)nuclear inner membrane (GO:0005637)nuclear membrane (GO:0031965)nuclear outer membrane (GO:0005640)nuclear pore (GO:0005643)nuclear pore central transport channel (GO:0044613)nucleocytoplasmic transport (GO:0006913)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)protein binding (GO:0005515)protein export from nucleus (GO:0006611)protein import into nucleus (GO:0006606)protein import into nucleus (GO:0006606)protein import into nucleus (GO:0006606)protein localization to nuclear pore (GO:0090204)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)structural constituent of nuclear pore (GO:0017056)

Expression (TPM)

TFs regulating NUTF2 0 TFs

Transcription factors with Perturb-seq knockdown data for NUTF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUTF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NUTF2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUTF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:67,561,597–67,563,672	284.6 kb	Distal (>10kb) Multiome	1044
chr16:67,644,719–67,645,304	202.0 kb	Distal (>10kb) Multiome	638
chr16:67,649,353–67,649,999	197.2 kb	Distal (>10kb) Multiome	112
chr16:67,652,610–67,653,810	194.0 kb	Distal (>10kb) Multiome	498
chr16:67,659,631–67,661,707	186.1 kb	Distal (>10kb) Multiome HiCAR	962
chr16:67,666,180–67,667,235	180.3 kb	Distal (>10kb) Multiome HiCAR	713
chr16:67,667,674–67,668,349	178.8 kb	Distal (>10kb) Multiome HiCAR	628
chr16:67,718,772–67,720,138	127.6 kb	Distal (>10kb) Multiome	866
chr16:67,806,066–67,807,386	40.2 kb	Distal (>10kb) Multiome	914
chr16:67,816,404–67,816,888	30.2 kb	Distal (>10kb) Multiome	690
chr16:67,833,426–67,834,269	13.0 kb	Distal (>10kb) Multiome	838
chr16:67,841,337–67,843,276	4.8 kb	Proximal (<10kb) Multiome	927
chr16:67,846,090–67,847,897	182 bp	At TSS Multiome	1025
chr16:67,872,739–67,873,665	26.1 kb	Distal (>10kb) Multiome	982
chr16:67,884,566–67,885,097	37.9 kb	Distal (>10kb) Multiome	264
chr16:67,892,898–67,893,885	46.3 kb	Distal (>10kb) Multiome	867
chr16:67,915,108–67,915,887	68.5 kb	Distal (>10kb) Multiome	92
chr16:67,935,189–67,936,596	88.9 kb	Distal (>10kb) Multiome	980
chr16:67,963,746–67,964,209	117.0 kb	Distal (>10kb) Multiome	161
chr16:67,968,087–67,969,341	121.7 kb	Distal (>10kb) Multiome	861
chr16:67,993,130–67,993,736	146.5 kb	Distal (>10kb) Multiome	790
chr16:68,019,222–68,020,043	172.5 kb	Distal (>10kb) Multiome	108
chr16:68,022,490–68,023,556	176.3 kb	Distal (>10kb) Multiome	958
chr16:68,084,205–68,086,133	238.3 kb	Distal (>10kb) Multiome	1092

Genome Browser

Genomic view of the NUTF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.