This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for SLC12A4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC12A4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC12A4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,659,631–67,661,707 | 307.8 kb | Distal (>10kb) Multiome HiCAR | 962 | |
| chr16:67,666,180–67,667,235 | 302.0 kb | Distal (>10kb) Multiome | 713 | |
| chr16:67,667,674–67,668,349 | 300.6 kb | Distal (>10kb) Multiome | 628 | |
| chr16:67,718,772–67,720,138 | 249.3 kb | Distal (>10kb) Multiome | 866 | |
| chr16:67,806,066–67,807,386 | 161.9 kb | Distal (>10kb) Multiome | 914 | |
| chr16:67,816,404–67,816,888 | 151.9 kb | Distal (>10kb) Multiome | 690 | |
| chr16:67,833,426–67,834,269 | 134.8 kb | Distal (>10kb) Multiome | 838 | |
| chr16:67,841,337–67,843,276 | 126.5 kb | Distal (>10kb) Multiome | 927 | |
| chr16:67,846,090–67,847,897 | 121.9 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:67,872,739–67,873,665 | 95.6 kb | Distal (>10kb) Multiome | 982 | |
| chr16:67,884,566–67,885,097 | 83.8 kb | Distal (>10kb) Multiome | 264 | |
| chr16:67,892,898–67,893,885 | 75.5 kb | Distal (>10kb) Multiome | 867 | |
| chr16:67,915,108–67,915,887 | 53.2 kb | Distal (>10kb) Multiome | 92 | |
| chr16:67,935,189–67,936,596 | 32.8 kb | Distal (>10kb) Multiome | 980 | |
| chr16:67,963,746–67,964,209 | 4.7 kb | Proximal (<10kb) Multiome | 161 | |
| chr16:67,968,087–67,969,341 | 22 bp | At TSS Multiome | 861 | |
| chr16:67,969,477–67,970,024 | 2.6 kb | Proximal (<10kb) | 307 | |
| chr16:67,993,130–67,993,736 | 24.8 kb | Distal (>10kb) Multiome | 790 | |
| chr16:68,019,222–68,020,043 | 50.8 kb | Distal (>10kb) Multiome | 108 | |
| chr16:68,022,490–68,023,556 | 54.5 kb | Distal (>10kb) Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 116.6 kb | Distal (>10kb) Multiome | 1092 | |
| chr16:68,235,016–68,238,254 | 267.5 kb | Distal (>10kb) Multiome | 1055 | |
| chr16:68,239,582–68,240,355 | 271.4 kb | Distal (>10kb) Multiome | 223 | |
| chr16:68,244,730–68,245,757 | 276.6 kb | Distal (>10kb) Multiome | 803 | |
| chr16:68,264,033–68,265,087 | 295.8 kb | Distal (>10kb) Multiome | 876 |
Genomic view of the SLC12A4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.