This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ACD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,393,199–67,393,789 | 266.8 kb | Distal (>10kb) Multiome | 377 | |
| chr16:67,396,006–67,396,718 | 263.8 kb | Distal (>10kb) Multiome | 375 | |
| chr16:67,399,230–67,399,872 | 260.7 kb | Distal (>10kb) Multiome | 211 | |
| chr16:67,415,996–67,416,812 | 243.9 kb | Distal (>10kb) Multiome | 687 | |
| chr16:67,428,012–67,428,783 | 232.0 kb | Distal (>10kb) Multiome | 382 | |
| chr16:67,430,407–67,432,610 | 229.2 kb | Distal (>10kb) Multiome | 790 | |
| chr16:67,480,508–67,481,841 | 179.1 kb | Distal (>10kb) Multiome HiCAR | 1002 | |
| chr16:67,521,086–67,521,812 | 138.8 kb | Distal (>10kb) Multiome HiCAR | 775 | |
| chr16:67,528,470–67,529,464 | 131.5 kb | Distal (>10kb) Multiome HiCAR | 641 | |
| chr16:67,537,215–67,538,620 | 122.2 kb | Distal (>10kb) Multiome HiCAR | 560 | |
| chr16:67,561,597–67,563,672 | 98.0 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:67,644,719–67,645,304 | 15.3 kb | Distal (>10kb) Multiome | 638 | |
| chr16:67,649,353–67,649,999 | 10.6 kb | Distal (>10kb) Multiome | 112 | |
| chr16:67,652,610–67,653,810 | 7.3 kb | Proximal (<10kb) Multiome | 498 | |
| chr16:67,659,631–67,661,707 | 529 bp | At TSS Multiome | 962 | |
| chr16:67,666,180–67,667,235 | 6.3 kb | Proximal (<10kb) Multiome | 713 | |
| chr16:67,667,674–67,668,349 | 7.8 kb | Proximal (<10kb) Multiome | 628 | |
| chr16:67,718,772–67,720,138 | 59.1 kb | Distal (>10kb) Multiome HiCAR | 866 | |
| chr16:67,806,066–67,807,386 | 146.5 kb | Distal (>10kb) Multiome | 914 | |
| chr16:67,816,404–67,816,888 | 156.5 kb | Distal (>10kb) Multiome | 690 | |
| chr16:67,833,426–67,834,269 | 173.6 kb | Distal (>10kb) Multiome | 838 | |
| chr16:67,841,337–67,843,276 | 181.8 kb | Distal (>10kb) Multiome HiCAR | 927 | |
| chr16:67,846,090–67,847,897 | 186.5 kb | Distal (>10kb) Multiome HiCAR | 1025 | |
| chr16:67,872,739–67,873,665 | 212.8 kb | Distal (>10kb) Multiome | 982 | |
| chr16:67,884,566–67,885,097 | 224.6 kb | Distal (>10kb) Multiome | 264 | |
| chr16:67,892,898–67,893,885 | 232.9 kb | Distal (>10kb) Multiome | 867 | |
| chr16:67,915,108–67,915,887 | 255.1 kb | Distal (>10kb) Multiome | 92 | |
| chr16:67,935,189–67,936,596 | 275.5 kb | Distal (>10kb) Multiome | 980 | |
| chr16:67,963,746–67,964,209 | 303.7 kb | Distal (>10kb) Multiome HiCAR | 161 | |
| chr16:67,968,087–67,969,341 | 308.4 kb | Distal (>10kb) Multiome HiCAR | 861 |
Genomic view of the ACD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.