ETV4

ETS variant transcription factor 4 | E1A-F, E1AF, PEA3

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of keratinocyte differentiation and positive regulation of transcription by RNA polymerase II. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC4

Biological processes 20 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cell differentiation (GO:0030154)chromatin (GO:0000785)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of keratinocyte differentiation (GO:0045618)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating ETV4 0 TFs

Transcription factors with Perturb-seq knockdown data for ETV4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ETV4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ETV4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ETV4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:43,359,784–43,361,254	185.2 kb	Distal (>10kb) Multiome	981
chr17:43,367,132–43,369,458	177.1 kb	Distal (>10kb) Multiome	1146
chr17:43,388,101–43,389,658	156.9 kb	Distal (>10kb) Multiome	770
chr17:43,396,555–43,396,987	149.6 kb	Distal (>10kb) Multiome	27
chr17:43,398,359–43,400,469	147.4 kb	Distal (>10kb) Multiome	827
chr17:43,403,154–43,404,714	142.4 kb	Distal (>10kb) Multiome	252
chr17:43,406,748–43,407,604	139.1 kb	Distal (>10kb) Multiome	102
chr17:43,438,695–43,439,408	107.3 kb	Distal (>10kb) Multiome	86
chr17:43,457,977–43,459,063	87.8 kb	Distal (>10kb) Multiome	328
chr17:43,483,594–43,484,268	62.5 kb	Distal (>10kb) Multiome	1016
chr17:43,530,368–43,531,356	15.4 kb	Distal (>10kb) Multiome	828
chr17:43,545,066–43,547,010	665 bp	At TSS Multiome	999
chr17:43,554,999–43,555,815	9.6 kb	Proximal (<10kb)	140
chr17:43,694,216–43,694,699	148.2 kb	Distal (>10kb) Multiome	408
chr17:43,720,542–43,721,150	174.5 kb	Distal (>10kb) Multiome	572
chr17:43,755,308–43,755,795	209.2 kb	Distal (>10kb) Multiome	248
chr17:43,760,231–43,760,686	214.2 kb	Distal (>10kb) Multiome	539
chr17:43,778,079–43,779,460	232.5 kb	Distal (>10kb) Multiome	937
chr17:43,832,658–43,833,385	286.9 kb	Distal (>10kb) Multiome	455

Genome Browser

Genomic view of the ETV4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.