This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for DUS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,806,066–67,807,386 | 216.5 kb | Distal (>10kb) Multiome | 914 | |
| chr16:67,816,404–67,816,888 | 206.5 kb | Distal (>10kb) Multiome | 690 | |
| chr16:67,833,426–67,834,269 | 189.4 kb | Distal (>10kb) Multiome | 838 | |
| chr16:67,841,337–67,843,276 | 181.2 kb | Distal (>10kb) Multiome | 927 | |
| chr16:67,846,090–67,847,897 | 176.5 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:67,872,739–67,873,665 | 150.2 kb | Distal (>10kb) Multiome | 982 | |
| chr16:67,884,566–67,885,097 | 138.4 kb | Distal (>10kb) Multiome | 264 | |
| chr16:67,892,898–67,893,885 | 130.1 kb | Distal (>10kb) Multiome | 867 | |
| chr16:67,915,108–67,915,887 | 107.9 kb | Distal (>10kb) Multiome | 92 | |
| chr16:67,935,189–67,936,596 | 87.5 kb | Distal (>10kb) Multiome | 980 | |
| chr16:67,963,746–67,964,209 | 59.3 kb | Distal (>10kb) Multiome | 161 | |
| chr16:67,968,087–67,969,341 | 54.6 kb | Distal (>10kb) Multiome | 861 | |
| chr16:67,993,130–67,993,736 | 29.8 kb | Distal (>10kb) Multiome | 790 | |
| chr16:68,019,222–68,020,043 | 3.8 kb | Proximal (<10kb) Multiome | 108 | |
| chr16:68,022,490–68,023,556 | 81 bp | At TSS Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 62.0 kb | Distal (>10kb) Multiome | 1092 | |
| chr16:68,235,016–68,238,254 | 212.9 kb | Distal (>10kb) Multiome | 1055 | |
| chr16:68,239,582–68,240,355 | 216.7 kb | Distal (>10kb) Multiome | 223 | |
| chr16:68,244,730–68,245,757 | 222.0 kb | Distal (>10kb) Multiome | 803 | |
| chr16:68,264,033–68,265,087 | 241.2 kb | Distal (>10kb) Multiome | 876 | |
| chr16:68,310,451–68,311,505 | 287.7 kb | Distal (>10kb) Multiome | 1061 |
Genomic view of the DUS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.