THAP11

THAP domain containing 11 | CTG-B43a, CTG-B45d, HRIHFB2206, RONIN

The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.20

Biological processes 18 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)core promoter sequence-specific DNA binding (GO:0001046)cytoplasm (GO:0005737)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating THAP11 0 TFs

Transcription factors with Perturb-seq knockdown data for THAP11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THAP11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to THAP11

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THAP11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:67,561,597–67,563,672	280.0 kb	Distal (>10kb) Multiome	1044
chr16:67,644,719–67,645,304	197.4 kb	Distal (>10kb) Multiome	638
chr16:67,649,353–67,649,999	192.6 kb	Distal (>10kb) Multiome	112
chr16:67,652,610–67,653,810	189.3 kb	Distal (>10kb) Multiome	498
chr16:67,659,631–67,661,707	181.5 kb	Distal (>10kb) Multiome HiCAR	962
chr16:67,666,180–67,667,235	175.7 kb	Distal (>10kb) Multiome HiCAR	713
chr16:67,667,674–67,668,349	174.2 kb	Distal (>10kb) Multiome HiCAR	628
chr16:67,718,772–67,720,138	123.0 kb	Distal (>10kb) Multiome	866
chr16:67,806,066–67,807,386	35.6 kb	Distal (>10kb) Multiome	914
chr16:67,816,404–67,816,888	25.6 kb	Distal (>10kb) Multiome	690
chr16:67,833,426–67,834,269	8.4 kb	Proximal (<10kb) Multiome	838
chr16:67,841,337–67,843,276	207 bp	At TSS Multiome	927
chr16:67,846,090–67,847,897	4.4 kb	Proximal (<10kb) Multiome	1025
chr16:67,872,739–67,873,665	30.7 kb	Distal (>10kb) Multiome	982
chr16:67,884,566–67,885,097	42.6 kb	Distal (>10kb) Multiome	264
chr16:67,892,898–67,893,885	50.9 kb	Distal (>10kb) Multiome	867
chr16:67,915,108–67,915,887	73.1 kb	Distal (>10kb) Multiome	92
chr16:67,935,189–67,936,596	93.5 kb	Distal (>10kb) Multiome	980
chr16:67,963,746–67,964,209	121.6 kb	Distal (>10kb) Multiome	161
chr16:67,968,087–67,969,341	126.4 kb	Distal (>10kb) Multiome	861
chr16:67,993,130–67,993,736	151.1 kb	Distal (>10kb) Multiome	790
chr16:68,019,222–68,020,043	177.1 kb	Distal (>10kb) Multiome	108
chr16:68,022,490–68,023,556	180.9 kb	Distal (>10kb) Multiome	958
chr16:68,084,205–68,086,133	242.9 kb	Distal (>10kb) Multiome	1092

Genome Browser

Genomic view of the THAP11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.