RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for RANBP10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RANBP10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RANBP10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,521,086–67,521,812 | 285.1 kb | Distal (>10kb) Multiome | 775 | |
| chr16:67,528,470–67,529,464 | 277.7 kb | Distal (>10kb) Multiome | 641 | |
| chr16:67,537,215–67,538,620 | 268.5 kb | Distal (>10kb) Multiome | 560 | |
| chr16:67,561,597–67,563,672 | 244.3 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:67,644,719–67,645,304 | 161.6 kb | Distal (>10kb) Multiome | 638 | |
| chr16:67,649,353–67,649,999 | 156.9 kb | Distal (>10kb) Multiome | 112 | |
| chr16:67,652,610–67,653,810 | 153.6 kb | Distal (>10kb) Multiome | 498 | |
| chr16:67,659,631–67,661,707 | 145.7 kb | Distal (>10kb) Multiome | 962 | |
| chr16:67,666,180–67,667,235 | 139.9 kb | Distal (>10kb) Multiome | 713 | |
| chr16:67,667,674–67,668,349 | 138.5 kb | Distal (>10kb) Multiome | 628 | |
| chr16:67,718,772–67,720,138 | 87.2 kb | Distal (>10kb) Multiome | 866 | |
| chr16:67,806,066–67,807,386 | 198 bp | At TSS Multiome | 914 | |
| chr16:67,816,404–67,816,888 | 10.2 kb | Distal (>10kb) Multiome | 690 | |
| chr16:67,833,426–67,834,269 | 27.3 kb | Distal (>10kb) Multiome | 838 | |
| chr16:67,841,337–67,843,276 | 35.6 kb | Distal (>10kb) Multiome | 927 | |
| chr16:67,846,090–67,847,897 | 40.2 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:67,872,739–67,873,665 | 66.5 kb | Distal (>10kb) Multiome | 982 | |
| chr16:67,884,566–67,885,097 | 78.3 kb | Distal (>10kb) Multiome | 264 | |
| chr16:67,892,898–67,893,885 | 86.6 kb | Distal (>10kb) Multiome | 867 | |
| chr16:67,915,108–67,915,887 | 108.9 kb | Distal (>10kb) Multiome | 92 | |
| chr16:67,935,189–67,936,596 | 129.2 kb | Distal (>10kb) Multiome | 980 | |
| chr16:67,963,746–67,964,209 | 157.4 kb | Distal (>10kb) Multiome | 161 | |
| chr16:67,968,087–67,969,341 | 162.1 kb | Distal (>10kb) Multiome | 861 | |
| chr16:67,993,130–67,993,736 | 186.9 kb | Distal (>10kb) Multiome | 790 | |
| chr16:68,019,222–68,020,043 | 212.9 kb | Distal (>10kb) Multiome | 108 | |
| chr16:68,022,490–68,023,556 | 216.6 kb | Distal (>10kb) Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 278.7 kb | Distal (>10kb) Multiome | 1092 |
Genomic view of the RANBP10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.