This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ELK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:205,343,395–205,344,420 | 288.1 kb | Distal (>10kb) Multiome | 395 | |
| chr1:205,430,507–205,431,109 | 201.2 kb | Distal (>10kb) Multiome | 387 | |
| chr1:205,440,982–205,441,976 | 190.8 kb | Distal (>10kb) Multiome | 341 | |
| chr1:205,444,530–205,445,576 | 186.8 kb | Distal (>10kb) Multiome | 351 | |
| chr1:205,447,468–205,447,874 | 184.5 kb | Distal (>10kb) Multiome | 135 | |
| chr1:205,448,352–205,449,283 | 183.3 kb | Distal (>10kb) Multiome | 269 | |
| chr1:205,449,573–205,450,965 | 181.9 kb | Distal (>10kb) Multiome | 512 | |
| chr1:205,456,289–205,457,681 | 174.8 kb | Distal (>10kb) Multiome | 383 | |
| chr1:205,485,282–205,485,813 | 146.4 kb | Distal (>10kb) Multiome | 590 | |
| chr1:205,502,456–205,503,022 | 129.3 kb | Distal (>10kb) Multiome | 45 | |
| chr1:205,504,221–205,505,625 | 127.4 kb | Distal (>10kb) Multiome | 631 | |
| chr1:205,528,647–205,529,482 | 102.9 kb | Distal (>10kb) Multiome | 390 | |
| chr1:205,543,280–205,544,028 | 88.4 kb | Distal (>10kb) Multiome | 371 | |
| chr1:205,591,729–205,592,393 | 39.9 kb | Distal (>10kb) Multiome | 624 | |
| chr1:205,631,034–205,632,587 | 173 bp | At TSS Multiome | 1054 | |
| chr1:205,670,539–205,671,380 | 38.8 kb | Distal (>10kb) Multiome | 189 | |
| chr1:205,679,697–205,680,913 | 48.5 kb | Distal (>10kb) Multiome | 568 | |
| chr1:205,706,859–205,707,298 | 74.9 kb | Distal (>10kb) Multiome | 145 | |
| chr1:205,748,908–205,750,848 | 117.5 kb | Distal (>10kb) Multiome | 1074 | |
| chr1:205,774,834–205,775,616 | 143.4 kb | Distal (>10kb) Multiome | 637 | |
| chr1:205,812,462–205,814,100 | 181.3 kb | Distal (>10kb) Multiome | 693 | |
| chr1:205,849,914–205,850,368 | 218.2 kb | Distal (>10kb) Multiome | 143 | |
| chr1:205,918,766–205,919,275 | 287.1 kb | Distal (>10kb) Multiome | 284 |
Genomic view of the ELK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.