chr22:46,627,272–46,627,735

chr22 : 46,627,272 – 46,627,735

463 bp 93 TFs 6 linked genes

This 463 bp open chromatin element is linked to 6 target genes and is bound by 93 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
GRAMD4		50.4 kb	Distal	Multiome
CELSR1		90.0 kb	Distal	Multiome
CERK		110.6 kb	Distal	Multiome
TBC1D22A-DT		135.0 kb	Distal	Multiome
TBC1D22A		135.1 kb	Distal	Multiome
TRMU		291.8 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

93 transcription factors

ChIP NALM-6 GSE93626.AATF.NALM-6 106 bp overlap

ChIP K-562 ENCSR641BSL.AGO1.K-562 315 bp overlap

ChIP MDA-MB-453 ERP003503.AR.MDA-MB-453 429 bp overlap

ChIP MDA-MB-453_FOXA1 ERP003503.AR.MDA-MB-453_FOXA1 440 bp overlap

ChIP prostate_fetal-fibroblast GSE90772.AR.prostate_fetal-fibroblast 272 bp overlap

ARNT 2 datasets

ChIP 501-mel GSE95280.ARNT.501-mel 71 bp overlap

ChIP MCF-7_aza GSE85352.ARNT.MCF-7_aza 224 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 67 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 128 bp overlap

BRD4 5 datasets

ChIP CLL_patient2 GSE109411.BRD4.CLL_patient2 202 bp overlap

ChIP CLL_patient4_4h_CpG_BET GSE109411.BRD4.CLL_patient4_4h_CpG_BET 322 bp overlap

ChIP K-562_iBET-BD2 GSE138084.BRD4.K-562_iBET-BD2 414 bp overlap

ChIP hESC GSE33281.BRD4.hESC 226 bp overlap

ChIP keratinocyte GSE140992.BRD4.keratinocyte 315 bp overlap

ChIP HEK293T GSE34774.CBX2.HEK293T 126 bp overlap

ChIP HCT-116 GSE72622.CDK9.HCT-116 216 bp overlap

ChIP WA01 ENCSR000EBT.CHD2.WA01 152 bp overlap

CREBBP 1 dataset

ChIP keratinocyte_KLF3i GSE140991.CREBBP.keratinocyte_KLF3i 266 bp overlap

ChIP prostate_gland ENCSR720USO.CTCF.prostate_gland 90 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF364PUR 251 bp overlap

ChIP BLaER1 ENCFF460KDD 333 bp overlap

DNMT3B 1 dataset

ChIP HUES-8_TripleKO-TET1-2-3 GSE99346.DNMT3B.HUES-8_TripleKO-TET1-2-3 247 bp overlap

E2F6 3 datasets

ChIP H1 ENCFF785DWK 241 bp overlap

ChIP H1 ENCFF785DWK 446 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 341 bp overlap

ChIP A-375 GSE116190.EGR1.A-375 172 bp overlap

EP300 1 dataset

ChIP WA01 ENCSR000BKK.EP300.WA01 128 bp overlap

ESR1 9 datasets

ChIP Ishikawa GSE99905.ESR1.Ishikawa 325 bp overlap

ChIP Ishikawa_DMSO GSE132426.ESR1.Ishikawa_DMSO 195 bp overlap

ChIP Ishikawa_DMSO_D538G_clone3 GSE132426.ESR1.Ishikawa_DMSO_D538G_clone3 132 bp overlap

ChIP Ishikawa_E2 GSE132426.ESR1.Ishikawa_E2 277 bp overlap

ChIP Ishikawa_E2_clone2 GSE132426.ESR1.Ishikawa_E2_clone2 253 bp overlap

ChIP Ishikawa_ETV4-OE GSE129803.ESR1.Ishikawa_ETV4-OE 243 bp overlap

ChIP Ishikawa_siETV4-72h GSE129803.ESR1.Ishikawa_siETV4-72h 214 bp overlap

ChIP Ishikawa_siNTC-72h GSE129803.ESR1.Ishikawa_siNTC-72h 302 bp overlap

ChIP Ishikawa_siNTC-96h GSE129803.ESR1.Ishikawa_siNTC-96h 252 bp overlap

FOXA1 1 dataset

ChIP prostate_2480 GSE130408.FOXA1.prostate_2480 294 bp overlap

FOXA2 1 dataset

ChIP BJ1-hTERT_FoxHnf1aCoExp GSE90454.FOXA2.BJ1-hTERT_FoxHnf1aCoExp 308 bp overlap

FOXK1 2 datasets

ChIP WTC11 ENCFF875IGU 391 bp overlap

ChIP WTC11 ENCFF875IGU 200 bp overlap

GABPA 1 dataset

ChIP WA01 ENCSR000BIW.GABPA.WA01 321 bp overlap

GLIS1 1 dataset

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 227 bp overlap

GLIS2 1 dataset

ChIP HEK293 ENCSR535DIA.GLIS2.HEK293 280 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 428 bp overlap

ChIP K-562 ENCSR197ALX.HDGF.K-562 214 bp overlap

HEXIM1 1 dataset

ChIP HCT-116 GSE72622.HEXIM1.HCT-116 359 bp overlap

HOXA3 1 dataset

ChIP Hep-G2 ENCSR999JKC.HOXA3.Hep-G2 164 bp overlap

ChIP keratinocyte_DOX GSE135677.IRF2.keratinocyte_DOX 317 bp overlap

ChIP 786-O GSE86092.JUN.786-O 235 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 245 bp overlap

ChIP MDA-BoM-1833_shp27 GSE112444.JUN.MDA-BoM-1833_shp27 184 bp overlap

KDM4A 1 dataset

ChIP hiPSC_IIA11 GSE106870.KDM4A.hiPSC_IIA11 174 bp overlap

KDM5B 1 dataset

ChIP SUM185_SHCTCF GSE46055.KDM5B.SUM185_SHCTCF 130 bp overlap

ChIP HEK293 ENCSR859BMR.KLF1.HEK293 341 bp overlap

KLF17 1 dataset

ChIP HEK293 ENCSR065WUF.KLF17.HEK293 432 bp overlap

KLF4 2 datasets

ChIP keratinocyte_diff GSE57702.KLF4.keratinocyte_diff 87 bp overlap

ChIP keratinocyte_diff GSE57702.KLF4.keratinocyte_diff 105 bp overlap

KLF5 3 datasets

ChIP ESO-26 GSE132680.KLF5.ESO-26 460 bp overlap

ChIP HCC95 GSE88976.KLF5.HCC95 239 bp overlap

ChIP HEK293_D418N GSE88976.KLF5.HEK293_D418N 201 bp overlap

ChIP GBM1A GSE62211.KLF9.GBM1A 125 bp overlap

ChIP K-562 ENCSR000EFV.MAX.K-562 188 bp overlap

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 463 bp overlap

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 463 bp overlap

ChIP WTC11 ENCFF223QFY 463 bp overlap

ChIP HEK293 ENCSR290SSQ.MAZ.HEK293 228 bp overlap

ChIP HEK293 GSE76494.MAZ.HEK293 167 bp overlap

ChIP HUVEC-C_siCTL GSE124892.MED1.HUVEC-C_siCTL 187 bp overlap

ChIP K-562 ENCSR000EGJ.MYC.K-562 142 bp overlap

ChIP NCI-H128 GSE41105.MYC.NCI-H128 117 bp overlap

ChIP NCI-H128 GSE41105.MYC.NCI-H128 286 bp overlap

ChIP NCI-H2171 GSE36354.MYC.NCI-H2171 440 bp overlap

MYCN 2 datasets

ChIP Kelly GSE94782.MYCN.Kelly 152 bp overlap

ChIP LNCaP_DHT GSE117304.MYCN.LNCaP_DHT 255 bp overlap

MYOD1 1 dataset

ChIP IMR-90_GM GSE128527.MYOD1.IMR-90_GM 228 bp overlap

NANOG 1 dataset

ChIP HUES-8 GSE109524.NANOG.HUES-8 263 bp overlap

NCOA2 1 dataset

ChIP MCF-7_E2 ERP000901.NCOA2.MCF-7_E2 118 bp overlap

NR2C1 1 dataset

ChIP K562 ENCFF239KMA 57 bp overlap

NR3C1 1 dataset

ChIP Ishikawa ENCSR000BJC.NR3C1.Ishikawa 176 bp overlap

NRF1 2 datasets

ChIP HMEC-1 GSE67867.NRF1.HMEC-1 282 bp overlap

ChIP K-562 ENCSR998AJK.NRF1.K-562 315 bp overlap

OGG1 4 datasets

ChIP HEK293 GSE89017.OGG1.HEK293 362 bp overlap

ChIP HEK293_15min GSE89017.OGG1.HEK293_15min 312 bp overlap

ChIP HEK293_30_min GSE89017.OGG1.HEK293_30_min 287 bp overlap

ChIP HEK293_60_min GSE89017.OGG1.HEK293_60_min 350 bp overlap

PATZ1 2 datasets

ChIP HEK293 ENCFF016MNJ 463 bp overlap

ChIP HEK293 ENCSR966ULI.PATZ1.HEK293 271 bp overlap

POLR2A 7 datasets

ChIP prostate gland ENCFF832RQK 118 bp overlap

ChIP prostate gland ENCFF881OMH 354 bp overlap

ChIP suprapubic skin ENCFF083NEJ 331 bp overlap

ChIP suprapubic skin ENCFF748PRQ 277 bp overlap

ChIP vagina ENCFF305NWS 262 bp overlap

ChIP vagina ENCFF305NWS 211 bp overlap

ChIP vagina ENCFF384GAB 463 bp overlap

POU2F1 1 dataset

ChIP 22Rv1_Veh GSE123565.POU2F1.22Rv1_Veh 160 bp overlap

POU4F2 1 dataset

ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 148 bp overlap

POU5F1 6 datasets

ChIP BG03 GSE21614.POU5F1.BG03 114 bp overlap

ChIP BG03 GSE21614.POU5F1.BG03 168 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 463 bp overlap

ChIP SKM-1 GSE93706.POU5F1.SKM-1 396 bp overlap

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 249 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 463 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 463 bp overlap

RBBP5 2 datasets

ChIP WA01 ENCSR000AQC.RBBP5.WA01 185 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 89 bp overlap

RBFOX2 2 datasets

ChIP K-562 ENCSR822LBD.RBFOX2.K-562 398 bp overlap

ChIP K-562 GSE120104.RBFOX2.K-562 208 bp overlap

RBM14 1 dataset

ChIP K-562 ENCSR423FCW.RBM14.K-562 224 bp overlap

RBM22 1 dataset

ChIP K-562 GSE120104.RBM22.K-562 381 bp overlap

ChIP SCC_4h GSE156486.RBPJ.SCC_4h 179 bp overlap

RELA 2 datasets

ChIP FaDu_LPS GSE132018.RELA.FaDu_LPS 312 bp overlap

ChIP HEK293_TNF-1h GSE75562.RELA.HEK293_TNF-1h 463 bp overlap

RORC 2 datasets

ChIP HCC70 GSE126380.RORC.HCC70 438 bp overlap

ChIP HCC70_XY018 GSE126380.RORC.HCC70_XY018 463 bp overlap

ChIP WA01 GSE104690.RYBP.WA01 301 bp overlap

SIN3A 1 dataset

ChIP hiPSC_IB12 GSE106870.SIN3A.hiPSC_IB12 176 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 457 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 248 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 463 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 316 bp overlap

ChIP ESC S23-ESC-d0-SMAD2_3-exp1 284 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 264 bp overlap

SMAD3 1 dataset

ChIP BG03 GSE21614.SMAD3.BG03 147 bp overlap

SMC1A 3 datasets

ChIP primary-epidermal-keratinocyte GSE85526.SMC1A.primary-epidermal-keratinocyte 417 bp overlap

ChIP primary-epidermal-keratinocyte_diff_d3 GSE84657.SMC1A.primary-epidermal-keratinocyte_diff_d3 463 bp overlap

ChIP primary-epidermal-keratinocyte_diff_d6 GSE84657.SMC1A.primary-epidermal-keratinocyte_diff_d6 187 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 180 bp overlap

ChIP WTC11 ENCFF688PEU 420 bp overlap

ChIP HEK293 GSE76494.SP4.HEK293 274 bp overlap

SREBP2 2 datasets

ChIP HCC70 GSE126380.SREBP2.HCC70 453 bp overlap

ChIP HCC70_XY018 GSE126380.SREBP2.HCC70_XY018 268 bp overlap

ChIP H1 ENCFF036PEF 205 bp overlap

ChIP Ishikawa ENCFF992QXM 176 bp overlap

ChIP Ishikawa ENCSR000BTD.SRF.Ishikawa 261 bp overlap

ChIP WA01 ENCSR000BIV.SRF.WA01 285 bp overlap

STAT3 2 datasets

ChIP FaDu_BB608 GSE78212.STAT3.FaDu_BB608 463 bp overlap

ChIP FaDu_DMSO GSE78212.STAT3.FaDu_DMSO 360 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 131 bp overlap

TARDBP 1 dataset

ChIP Hep-G2 ENCSR145CXH.TARDBP.Hep-G2 152 bp overlap

ChIP WA01 ENCSR000ECB.TBP.WA01 123 bp overlap

TCF12 3 datasets

ChIP Ishikawa ENCFF467DDW 385 bp overlap

ChIP Ishikawa ENCSR000BUV.TCF12.Ishikawa 176 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 140 bp overlap

TEAD1 1 dataset

ChIP H69 GSE62274.TEAD1.H69 154 bp overlap

TFAP2C 2 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 295 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 325 bp overlap

TP53 3 datasets

ChIP SaOS-2 GSE51268.TP53.SaOS-2 272 bp overlap

ChIP hESC_DAMAGED GSE39912.TP53.hESC_DAMAGED 312 bp overlap

ChIP keratinocyte_ADRIA GSE56674.TP53.keratinocyte_ADRIA 173 bp overlap

TP63 21 datasets

ChIP BxPC-3 GSE115461.TP63.BxPC-3 463 bp overlap

ChIP HCC95 GSE46837.TP63.HCC95 153 bp overlap

ChIP HaCaT_LacZ_TGFB GSE60814.TP63.HaCaT_LacZ_TGFB 463 bp overlap

ChIP HaCaT_caRAS_TGFB GSE60814.TP63.HaCaT_caRAS_TGFB 396 bp overlap

ChIP HaCaT_dnRAS_TGFB GSE60814.TP63.HaCaT_dnRAS_TGFB 288 bp overlap

ChIP KYSE-70 GSE46837.TP63.KYSE-70 247 bp overlap

ChIP MCF-10A_Nutlin3A GSE111009.TP63.MCF-10A_Nutlin3A 241 bp overlap

ChIP SCC-25 GSE104137.TP63.SCC-25 239 bp overlap

ChIP SUIT-2 GSE115461.TP63.SUIT-2 463 bp overlap

ChIP TT GSE46837.TP63.TT 154 bp overlap

ChIP breast-organoid GSE113909.TP63.breast-organoid 374 bp overlap

ChIP keratinocyte GSE56674.TP63.keratinocyte 349 bp overlap

ChIP keratinocyte GSE33571.TP63.keratinocyte 327 bp overlap

ChIP keratinocyte_CISP GSE56674.TP63.keratinocyte_CISP 406 bp overlap

ChIP keratinocyte_D0 GSE59824.TP63.keratinocyte_D0 447 bp overlap

ChIP keratinocyte_D2 GSE59824.TP63.keratinocyte_D2 442 bp overlap

ChIP keratinocyte_D4 GSE59824.TP63.keratinocyte_D4 435 bp overlap

ChIP keratinocyte_D7 GSE59824.TP63.keratinocyte_D7 338 bp overlap

ChIP keratinocyte_diff GSE33571.TP63.keratinocyte_diff 463 bp overlap

ChIP keratinocyte_epidermal GSE67382.TP63.keratinocyte_epidermal 349 bp overlap

ChIP keratinocyte_epidermal_KDPAF GSE67382.TP63.keratinocyte_epidermal_KDPAF 278 bp overlap

USF1 3 datasets

ChIP H1 ENCFF090WVU 90 bp overlap

ChIP WA01 ENCSR000BIU.USF1.WA01 50 bp overlap

ChIP WTC11 ENCFF699QGS 209 bp overlap

USF2 2 datasets

ChIP WTC11 ENCFF139JAW 190 bp overlap

ChIP WTC11 ENCFF139JAW 410 bp overlap

ChIP H1 ENCFF524BTL 266 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 208 bp overlap

ZBTB33 3 datasets

ChIP K-562 ENCSR876GXA.ZBTB33.K-562 326 bp overlap

ChIP K562 ENCFF427SDV 205 bp overlap

ChIP K562 ENCFF875HLX 84 bp overlap

ZBTB44 1 dataset

ChIP HEK293 ENCSR076STQ.ZBTB44.HEK293 158 bp overlap

ZBTB48 1 dataset

ChIP U2OS GSE96776.ZBTB48.U2OS 291 bp overlap

ChIP HEK293T_22Rv1 GSE145160.ZFX.HEK293T_22Rv1 463 bp overlap

ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 463 bp overlap

ChIP PrEC GSE102616.ZFX.PrEC 437 bp overlap

ZNF138 1 dataset

ChIP WTC11 ENCFF800FUU 248 bp overlap

ZNF148 1 dataset

ChIP K-562 ENCSR018MSO.ZNF148.K-562 257 bp overlap

ZNF449 2 datasets

ChIP HEK293 ENCFF764ZIC 312 bp overlap

ChIP HEK293 ENCSR738SLS.ZNF449.HEK293 248 bp overlap

ZNF736 1 dataset

ChIP HEK293T GSE78099.ZNF736.HEK293T 155 bp overlap

ZNF750 1 dataset

ChIP keratinocyte_diff GSE57702.ZNF750.keratinocyte_diff 331 bp overlap