This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for TRMU. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMU upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMU, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:46,035,443–46,036,717 | 299.8 kb | Distal (>10kb) Multiome | 735 | |
| chr22:46,061,373–46,062,193 | 274.0 kb | Distal (>10kb) Multiome | 257 | |
| chr22:46,070,177–46,072,638 | 264.7 kb | Distal (>10kb) Multiome | 557 | |
| chr22:46,116,470–46,116,929 | 219.1 kb | Distal (>10kb) Multiome | 471 | |
| chr22:46,149,521–46,151,433 | 185.4 kb | Distal (>10kb) Multiome | 562 | |
| chr22:46,201,176–46,201,774 | 134.2 kb | Distal (>10kb) Multiome | 124 | |
| chr22:46,249,918–46,250,866 | 85.4 kb | Distal (>10kb) Multiome | 831 | |
| chr22:46,262,531–46,263,383 | 72.8 kb | Distal (>10kb) Multiome | 169 | |
| chr22:46,267,542–46,268,277 | 67.8 kb | Distal (>10kb) Multiome | 725 | |
| chr22:46,296,072–46,297,498 | 38.9 kb | Distal (>10kb) Multiome | 810 | |
| chr22:46,333,222–46,333,540 | 2.2 kb | Proximal (<10kb) | 12 | |
| chr22:46,335,274–46,336,005 | 115 bp | At TSS Multiome | 911 | |
| chr22:46,536,494–46,538,050 | 201.9 kb | Distal (>10kb) Multiome | 337 | |
| chr22:46,563,410–46,564,218 | 228.1 kb | Distal (>10kb) Multiome | 541 | |
| chr22:46,576,506–46,577,542 | 241.4 kb | Distal (>10kb) Multiome | 332 | |
| chr22:46,627,272–46,627,735 | 291.8 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the TRMU locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.