Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB44. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB44 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB44, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:130,068,597–130,071,216 | 245.2 kb | Distal (>10kb) Multiome | 898 | |
| chr11:130,076,579–130,077,560 | 237.9 kb | Distal (>10kb) Multiome | 129 | |
| chr11:130,146,013–130,146,727 | 168.4 kb | Distal (>10kb) Multiome | 413 | |
| chr11:130,159,259–130,160,341 | 155.1 kb | Distal (>10kb) Multiome | 309 | |
| chr11:130,212,937–130,213,600 | 101.6 kb | Distal (>10kb) Multiome | 321 | |
| chr11:130,314,035–130,315,987 | 108 bp | At TSS Multiome | 766 | |
| chr11:130,378,066–130,378,569 | 63.5 kb | Distal (>10kb) Multiome | 64 | |
| chr11:130,383,295–130,383,854 | 68.7 kb | Distal (>10kb) Multiome | 272 | |
| chr11:130,423,717–130,424,508 | 109.0 kb | Distal (>10kb) Multiome | 77 | |
| chr11:130,427,546–130,428,649 | 113.3 kb | Distal (>10kb) Multiome | 234 | |
| chr11:130,448,217–130,449,643 | 133.7 kb | Distal (>10kb) Multiome | 449 | |
| chr11:130,449,732–130,450,570 | 135.3 kb | Distal (>10kb) Multiome | 212 | |
| chr11:130,560,154–130,560,797 | 245.4 kb | Distal (>10kb) Multiome | 124 |
Genomic view of the ZBTB44 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.