ARNT

aryl hydrocarbon receptor nuclear translocator | ARNT1, HIF-1beta, bHLHe2

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Member of: DE-10

Biological processes 55 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulator complex (GO:0090575)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)aryl hydrocarbon receptor binding (GO:0017162)aryl hydrocarbon receptor complex (GO:0034751)cellular response to hypoxia (GO:0071456)cellular response to oxidative stress (GO:0034599)chromatin (GO:0000785)cis-regulatory region sequence-specific DNA binding (GO:0000987)cytoplasm (GO:0005737)intracellular receptor signaling pathway (GO:0030522)negative regulation of inflammatory response (GO:0050728)nuclear aryl hydrocarbon receptor complex (GO:0034753)nuclear body (GO:0016604)nuclear receptor activity (GO:0004879)nuclear receptor activity (GO:0004879)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of endothelial cell proliferation (GO:0001938)positive regulation of erythrocyte differentiation (GO:0045648)positive regulation of glycolytic process (GO:0045821)positive regulation of hormone biosynthetic process (GO:0046886)positive regulation of protein sumoylation (GO:0033235)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of vascular endothelial growth factor production (GO:0010575)positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)protein binding (GO:0005515)protein dimerization activity (GO:0046983)protein heterodimerization activity (GO:0046982)protein heterodimerization activity (GO:0046982)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to hypoxia (GO:0001666)response to hypoxia (GO:0001666)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)sequence-specific double-stranded DNA binding (GO:1990837)transcription regulator complex (GO:0005667)xenobiotic metabolic process (GO:0006805)

Expression (TPM)

TFs regulating ARNT 0 TFs

Transcription factors with Perturb-seq knockdown data for ARNT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARNT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ARNT

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARNT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:150,560,828–150,562,623	315.2 kb	Distal (>10kb) Multiome HiCAR	897
chr1:150,578,554–150,580,300	297.0 kb	Distal (>10kb) Multiome	990
chr1:150,629,012–150,630,122	247.1 kb	Distal (>10kb) Multiome	875
chr1:150,634,804–150,635,486	241.4 kb	Distal (>10kb) Multiome	113
chr1:150,641,008–150,641,820	235.0 kb	Distal (>10kb) Multiome	66
chr1:150,696,984–150,697,716	179.3 kb	Distal (>10kb) Multiome	619
chr1:150,875,863–150,877,222	122 bp	At TSS Multiome	912
chr1:150,925,543–150,926,754	49.8 kb	Distal (>10kb) Multiome	813
chr1:150,973,876–150,975,458	98.3 kb	Distal (>10kb) Multiome	590
chr1:150,979,331–150,979,990	103.0 kb	Distal (>10kb) Multiome	562
chr1:150,981,212–150,981,672	104.8 kb	Distal (>10kb) Multiome	379
chr1:151,006,389–151,007,024	130.2 kb	Distal (>10kb) Multiome	496
chr1:151,008,116–151,008,852	131.9 kb	Distal (>10kb) Multiome	763
chr1:151,047,405–151,048,764	172.0 kb	Distal (>10kb) Multiome	714
chr1:151,059,187–151,059,842	183.1 kb	Distal (>10kb) Multiome	821
chr1:151,060,204–151,060,723	183.9 kb	Distal (>10kb) Multiome	346
chr1:151,070,369–151,071,463	194.6 kb	Distal (>10kb) Multiome	835
chr1:151,131,105–151,132,256	254.9 kb	Distal (>10kb) Multiome	247
chr1:151,145,115–151,147,333	270.2 kb	Distal (>10kb) Multiome	709
chr1:151,165,133–151,166,350	289.3 kb	Distal (>10kb) Multiome	940

Genome Browser

Genomic view of the ARNT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.