This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for RBM14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:66,316,861–66,317,347 | 299.5 kb | Distal (>10kb) Multiome | 164 | |
| chr11:66,328,223–66,328,781 | 288.1 kb | Distal (>10kb) Multiome | 662 | |
| chr11:66,344,804–66,345,488 | 271.5 kb | Distal (>10kb) Multiome | 731 | |
| chr11:66,347,078–66,348,463 | 268.8 kb | Distal (>10kb) Multiome | 866 | |
| chr11:66,370,733–66,372,576 | 244.8 kb | Distal (>10kb) Multiome | 800 | |
| chr11:66,408,467–66,409,206 | 207.9 kb | Distal (>10kb) Multiome | 569 | |
| chr11:66,421,258–66,422,129 | 194.9 kb | Distal (>10kb) Multiome | 1190 | |
| chr11:66,438,544–66,439,241 | 177.6 kb | Distal (>10kb) Multiome | 756 | |
| chr11:66,466,155–66,467,634 | 149.8 kb | Distal (>10kb) Multiome | 579 | |
| chr11:66,479,578–66,480,947 | 136.2 kb | Distal (>10kb) Multiome | 937 | |
| chr11:66,510,277–66,510,954 | 106.0 kb | Distal (>10kb) Multiome | 787 | |
| chr11:66,545,631–66,547,072 | 70.5 kb | Distal (>10kb) Multiome | 753 | |
| chr11:66,568,061–66,568,910 | 48.1 kb | Distal (>10kb) Multiome | 392 | |
| chr11:66,592,561–66,593,452 | 23.6 kb | Distal (>10kb) Multiome | 857 | |
| chr11:66,616,078–66,617,408 | 92 bp | At TSS Multiome | 1011 | |
| chr11:66,637,919–66,639,003 | 21.9 kb | Distal (>10kb) Multiome | 872 | |
| chr11:66,677,182–66,678,796 | 61.3 kb | Distal (>10kb) Multiome | 926 | |
| chr11:66,728,259–66,728,943 | 111.8 kb | Distal (>10kb) Multiome | 275 | |
| chr11:66,744,354–66,745,291 | 128.1 kb | Distal (>10kb) Multiome | 747 | |
| chr11:66,842,896–66,843,952 | 226.8 kb | Distal (>10kb) Multiome | 843 | |
| chr11:66,855,758–66,857,980 | 239.8 kb | Distal (>10kb) Multiome | 795 | |
| chr11:66,882,995–66,883,462 | 266.6 kb | Distal (>10kb) Multiome | 277 |
Genomic view of the RBM14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.