RBM22

RNA binding motif protein 22 | Cwc2, FLJ10290, ZC3H16, fSAP47

This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]

Member of: DE-1

Biological processes 28 terms

Prp19 complex (GO:0000974)RNA binding (GO:0003723)RNA binding (GO:0003723)U2-type catalytic step 1 spliceosome (GO:0071006)U2-type catalytic step 2 spliceosome (GO:0071007)U2-type catalytic step 2 spliceosome (GO:0071007)U6 snRNA binding (GO:0017070)U6 snRNA binding (GO:0017070)calcium-dependent protein binding (GO:0048306)catalytic step 2 spliceosome (GO:0071013)cellular response to xenobiotic stimulus (GO:0071466)cytoplasm (GO:0005737)cytoplasm (GO:0005737)mRNA cis splicing, via spliceosome (GO:0045292)mRNA splicing, via spliceosome (GO:0000398)mRNA splicing, via spliceosome (GO:0000398)metal ion binding (GO:0046872)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of RNA splicing (GO:0033120)positive regulation of protein export from nucleus (GO:0046827)positive regulation of protein import into nucleus (GO:0042307)pre-mRNA binding (GO:0036002)pre-mRNA binding (GO:0036002)protein binding (GO:0005515)

Expression (TPM)

TFs regulating RBM22 0 TFs

Transcription factors with Perturb-seq knockdown data for RBM22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RBM22

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:150,409,825–150,410,350	291.1 kb	Distal (>10kb) Multiome	299
chr5:150,412,530–150,413,063	288.3 kb	Distal (>10kb) Multiome	495
chr5:150,441,289–150,442,097	259.4 kb	Distal (>10kb) Multiome	188
chr5:150,449,356–150,450,212	251.2 kb	Distal (>10kb) Multiome	1068
chr5:150,458,741–150,459,365	242.1 kb	Distal (>10kb) Multiome	430
chr5:150,485,401–150,487,150	215.3 kb	Distal (>10kb) Multiome	761
chr5:150,577,977–150,578,481	122.8 kb	Distal (>10kb) Multiome HiCAR	149
chr5:150,624,424–150,625,067	76.3 kb	Distal (>10kb) Multiome	250
chr5:150,656,143–150,657,405	44.4 kb	Distal (>10kb) Multiome	607
chr5:150,670,030–150,670,981	30.5 kb	Distal (>10kb) Multiome HiCAR	69
chr5:150,671,571–150,672,919	28.7 kb	Distal (>10kb) Multiome HiCAR	303
chr5:150,700,548–150,701,464	28 bp	At TSS Multiome	858
chr5:150,758,281–150,759,438	57.8 kb	Distal (>10kb) Multiome	902
chr5:150,778,240–150,779,492	78.0 kb	Distal (>10kb) Multiome	723
chr5:150,783,348–150,783,999	82.6 kb	Distal (>10kb) Multiome	435
chr5:150,801,105–150,801,901	100.5 kb	Distal (>10kb) Multiome	382

Genome Browser

Genomic view of the RBM22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.