Transcription factors with Perturb-seq knockdown data for TBC1D22A-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D22A-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D22A-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:46,536,494–46,538,050 | 225.0 kb | Distal (>10kb) Multiome | 337 | |
| chr22:46,563,410–46,564,218 | 198.8 kb | Distal (>10kb) Multiome | 541 | |
| chr22:46,576,506–46,577,542 | 185.5 kb | Distal (>10kb) Multiome | 332 | |
| chr22:46,627,272–46,627,735 | 135.0 kb | Distal (>10kb) Multiome | 93 | |
| chr22:46,737,592–46,739,215 | 24.3 kb | Distal (>10kb) Multiome | 596 | |
| chr22:46,758,885–46,759,096 | 3.5 kb | Proximal (<10kb) | 278 | |
| chr22:46,762,030–46,763,235 | 55 bp | At TSS Multiome | 920 | |
| chr22:46,803,079–46,803,635 | 40.9 kb | Distal (>10kb) Multiome | 349 |
Genomic view of the TBC1D22A-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.