chr16:54,938,325–54,938,703

chr16 : 54,938,325 – 54,938,703

378 bp 99 TFs 5 linked genes

This 378 bp open chromatin element is linked to 5 target genes and is bound by 99 transcription factors.

Linked Genes

5 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000259725		at TSS	At TSS	Proximity
ENSG00000259711		3.4 kb	Proximal	Proximity
IRX5		7.5 kb	Proximal	Proximity
ENSG00000289307		7.7 kb	Proximal	Proximity
CRNDE		9.5 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

99 transcription factors

ChIP MDA-MB-453 ERP003503.AR.MDA-MB-453 283 bp overlap

ChIP MDA-MB-453_FOXA1 ERP003503.AR.MDA-MB-453_FOXA1 299 bp overlap

ChIP breast_tumor_Male_26 GSE104399.AR.breast_tumor_Male_26 282 bp overlap

ChIP myofibroblast GSE90772.AR.myofibroblast 314 bp overlap

ChIP prostate_fetal-fibroblast GSE90772.AR.prostate_fetal-fibroblast 311 bp overlap

ARID2 2 datasets

ChIP Aska-SS GSE108025.ARID2.Aska-SS 163 bp overlap

ChIP Aska-SS_shSSX GSE108025.ARID2.Aska-SS_shSSX 342 bp overlap

ChIP RCC4 GSE85352.ARNT.RCC4 186 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 378 bp overlap

ChIP GM12878 ENCSR469WII.BMI1.GM12878 206 bp overlap

BRD2 2 datasets

ChIP MDA-MB-231_JQ1_MGSK2801 GSE116879.BRD2.MDA-MB-231_JQ1_MGSK2801 153 bp overlap

ChIP MDA-MB-231_JQ1_MGSK2801_rDNA GSE116879.BRD2.MDA-MB-231_JQ1_MGSK2801_rDNA 153 bp overlap

BRD4 4 datasets

ChIP MCF-10A ERP003925.BRD4.MCF-10A 203 bp overlap

ChIP SUM185_DMSO GSE63581.BRD4.SUM185_DMSO 210 bp overlap

ChIP retina_AB1-FW20 GSE86981.BRD4.retina_AB1-FW20 378 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 378 bp overlap

ChIP ME-1 GSE46044.CBFB.ME-1 240 bp overlap

ChIP HepG2 ENCFF838BNI 259 bp overlap

ChIP hMSC GSE117084.CBX4.hMSC 134 bp overlap

CBX7 2 datasets

ChIP hESC GSE133412.CBX7.hESC 192 bp overlap

ChIP hESC_TKO GSE133412.CBX7.hESC_TKO 173 bp overlap

ChIP K-562 ENCSR000ATW.CBX8.K-562 190 bp overlap

ChIP HCT-116 GSE72622.CDK9.HCT-116 137 bp overlap

ChIP WA01 ENCSR000AQK.CHD1.WA01 289 bp overlap

COMMD3-BMI1,BMI1 1 dataset

ChIP GM12878 ENCFF249AMT 304 bp overlap

CTBP2 2 datasets

ChIP H1 ENCFF329MAX 67 bp overlap

ChIP WA01 ENCSR000EUO.CTBP2.WA01 157 bp overlap

CTCF 9 datasets

ChIP T-47D_Y537S GSE148277.CTCF.T-47D_Y537S 286 bp overlap

ChIP breast_epithelium ENCSR661NXJ.CTCF.breast_epithelium 147 bp overlap

ChIP breast_epithelium ENCSR661NXJ.CTCF.breast_epithelium 123 bp overlap

ChIP hESC_D15 GSE116862.CTCF.hESC_D15 134 bp overlap

ChIP heart left ventricle ENCFF842XRG 79 bp overlap

ChIP left ventricle myocardium inferior ENCFF161DPW 95 bp overlap

ChIP neural cell ENCFF335ADI 93 bp overlap

ChIP neural_progenitor ENCSR125NBL.CTCF.neural_progenitor 83 bp overlap

ChIP prostate_epithelial ENCSR196HOM.CTCF.prostate_epithelial 234 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF460KDD 127 bp overlap

E2F6 2 datasets

ChIP H1 ENCFF785DWK 213 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 378 bp overlap

EP300 1 dataset

ChIP tibial nerve ENCFF346AYA 209 bp overlap

ChIP CD34_NR29 GSE23730.ERG.CD34_NR29 227 bp overlap

ESR1 5 datasets

ChIP MCF-7_Tamoxifen GSE115607.ESR1.MCF-7_Tamoxifen 290 bp overlap

ChIP T-47D_Y537S GSE148277.ESR1.T-47D_Y537S 290 bp overlap

ChIP breast_tumor_Male_10 GSE104399.ESR1.breast_tumor_Male_10 245 bp overlap

ChIP breast_tumor_Male_26 GSE104399.ESR1.breast_tumor_Male_26 204 bp overlap

ChIP breast_tumor_Male_28 GSE104399.ESR1.breast_tumor_Male_28 167 bp overlap

ESR1_pS118 2 datasets

ChIP MCF-7_Veh_sc GSE117569.ESR1_pS118.MCF-7_Veh_sc 116 bp overlap

ChIP MCF-7_Veh_sc GSE117569.ESR1_pS118.MCF-7_Veh_sc 153 bp overlap

ETS1 3 datasets

ChIP HUVEC-C_12h GSE93030.ETS1.HUVEC-C_12h 168 bp overlap

ChIP HUVEC-C_VEGF_12H GSE41166.ETS1.HUVEC-C_VEGF_12H 168 bp overlap

ChIP HUVEC-C_VEGF_12h GSE109625.ETS1.HUVEC-C_VEGF_12h 168 bp overlap

EZH2 14 datasets

ChIP GM23338 ENCFF613YON 378 bp overlap

ChIP GM23338 ENCFF886DXX 229 bp overlap

ChIP H1 ENCFF232NZA 378 bp overlap

ChIP HUVEC-C_VEGF_12h GSE109625.EZH2.HUVEC-C_VEGF_12h 378 bp overlap

ChIP HUVEC-C_VEGF_1h GSE109625.EZH2.HUVEC-C_VEGF_1h 281 bp overlap

ChIP Hep-3B2-1-7 GSE128137.EZH2.Hep-3B2-1-7 378 bp overlap

ChIP fibroblast_DERMAL ENCSR000ASE.EZH2.fibroblast_DERMAL 378 bp overlap

ChIP hESC GSE113817.EZH2.hESC 319 bp overlap

ChIP hESC_KO GSE113817.EZH2.hESC_KO 246 bp overlap

ChIP hepatocyte ENCFF118DKH 77 bp overlap

ChIP hepatocyte ENCFF552DZB 298 bp overlap

ChIP neural cell ENCFF610EPB 235 bp overlap

ChIP neural progenitor cell ENCFF018MKA 378 bp overlap

ChIP neural progenitor cell ENCFF472NFV 378 bp overlap

EZH2_phosphoT487 1 dataset

ChIP GM23248 ENCSR096KPA.EZH2_phosphoT487.GM23248 51 bp overlap

FLI1 2 datasets

ChIP HUVEC-C GSE109695.FLI1.HUVEC-C 183 bp overlap

ChIP UAE_ZINC GSE23730.FLI1.UAE_ZINC 253 bp overlap

FOXA1 7 datasets

ChIP ZR751_E2 GSE72249.FOXA1.ZR751_E2 71 bp overlap

ChIP breast-cancer_Veh-2856 GSE128018.FOXA1.breast-cancer_Veh-2856 374 bp overlap

ChIP breast-cancer_Veh-2858 GSE128018.FOXA1.breast-cancer_Veh-2858 378 bp overlap

ChIP breast-cancer_heregulin GSE101407.FOXA1.breast-cancer_heregulin 281 bp overlap

ChIP breast_tumor_Female_7 GSE104399.FOXA1.breast_tumor_Female_7 234 bp overlap

ChIP breast_tumor_Male_13 GSE104399.FOXA1.breast_tumor_Male_13 306 bp overlap

ChIP breast_tumor_Male_19 GSE104399.FOXA1.breast_tumor_Male_19 206 bp overlap

FOXA2 1 dataset

ChIP BJ1-hTERT_FoxHnf1aCoExp GSE90454.FOXA2.BJ1-hTERT_FoxHnf1aCoExp 308 bp overlap

GABPA 1 dataset

ChIP WA01 ENCSR000BIW.GABPA.WA01 162 bp overlap

GATA3 1 dataset

ChIP breast_tumor_Male_21 GSE104399.GATA3.breast_tumor_Male_21 86 bp overlap

GATA4 1 dataset

ChIP DE DE-GATA4-2 185 bp overlap

GATA6 5 datasets

ChIP DE DE-GATA6-2 189 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 60 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 331 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 128 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 378 bp overlap

HDAC2 1 dataset

ChIP WA01 ENCSR000AVB.HDAC2.WA01 162 bp overlap

HDAC6 1 dataset

ChIP GM12878 ENCSR933EYC.HDAC6.GM12878 255 bp overlap

HEXIM1 1 dataset

ChIP HCT-116 GSE72622.HEXIM1.HCT-116 377 bp overlap

HIF1A 1 dataset

ChIP BEAS-2B_arsenic GSE145834.HIF1A.BEAS-2B_arsenic 167 bp overlap

HIF3A 1 dataset

ChIP Hep-3B2-1-7 GSE129491.HIF3A.Hep-3B2-1-7 230 bp overlap

HIVEP1 1 dataset

ChIP Hep-G2 ENCSR697WMX.HIVEP1.Hep-G2 322 bp overlap

HNRNPLL 4 datasets

ChIP Hep-G2 ENCSR804HMZ.HNRNPLL.Hep-G2 254 bp overlap

ChIP Hep-G2 GSE120104.HNRNPLL.Hep-G2 206 bp overlap

ChIP HepG2 ENCFF952XAB 378 bp overlap

ChIP HepG2 ENCFF952XAB 149 bp overlap

HOXB13 2 datasets

ChIP prostate_2030 GSE130408.HOXB13.prostate_2030 61 bp overlap

ChIP prostate_2484 GSE130408.HOXB13.prostate_2484 50 bp overlap

INO80 1 dataset

ChIP Huh-7 GSE97411.INO80.Huh-7 139 bp overlap

JARID2 3 datasets

ChIP AMIPS8 GSE48516.JARID2.AMIPS8 378 bp overlap

ChIP MRC-5_IPS25 GSE48516.JARID2.MRC-5_IPS25 378 bp overlap

ChIP UTEIPS4 GSE48516.JARID2.UTEIPS4 378 bp overlap

ChIP MDA-MB-231 GSE112444.JUN.MDA-MB-231 80 bp overlap

KDM4A 2 datasets

ChIP H1 ENCFF078LED 83 bp overlap

ChIP H1 ENCFF078LED 378 bp overlap

KDM5B 2 datasets

ChIP SUM185 GSE46055.KDM5B.SUM185 173 bp overlap

ChIP SUM185_SHCTCF GSE46055.KDM5B.SUM185_SHCTCF 309 bp overlap

KMT2A 1 dataset

ChIP blood_cord GSE83671.KMT2A.blood_cord 210 bp overlap

ChIP H1 ENCFF914VQY 288 bp overlap

ChIP HepG2 ENCFF900ZJD 378 bp overlap

MLLT3 1 dataset

ChIP HSPC_MLLT3-virus GSE111482.MLLT3.HSPC_MLLT3-virus 378 bp overlap

MORC2 1 dataset

ChIP H9 GSE95374.MORC2.H9 296 bp overlap

ChIP DU145_SH4 GSE135623.MTF2.DU145_SH4 270 bp overlap

ChIP MDA-MB-453_DHT GSE45201.MYC.MDA-MB-453_DHT 224 bp overlap

MYCN 2 datasets

ChIP COG-N-415 GSE138295.MYCN.COG-N-415 271 bp overlap

ChIP LA-N-5 GSE138295.MYCN.LA-N-5 378 bp overlap

NANOG 2 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 378 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 170 bp overlap

NCAPH2 1 dataset

ChIP HEK293 GSE97540.NCAPH2.HEK293 144 bp overlap

OGG1 4 datasets

ChIP HEK293 GSE89017.OGG1.HEK293 143 bp overlap

ChIP HEK293_15min GSE89017.OGG1.HEK293_15min 293 bp overlap

ChIP HEK293_30_min GSE89017.OGG1.HEK293_30_min 228 bp overlap

ChIP HEK293_60_min GSE89017.OGG1.HEK293_60_min 174 bp overlap

ChIP retina_pigment GSE60024.PAX6.retina_pigment 374 bp overlap

PCGF2 1 dataset

ChIP NT2-D1 GSE101538.PCGF2.NT2-D1 378 bp overlap

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 378 bp overlap

ChIP breast_tumor_Male_26 GSE104399.PGR.breast_tumor_Male_26 91 bp overlap

PLAG1 1 dataset

ChIP K-562 GSE111469.PLAG1.K-562 133 bp overlap

POLR2A 23 datasets

ChIP breast epithelium ENCFF065JSZ 210 bp overlap

ChIP breast epithelium ENCFF955FMX 369 bp overlap

ChIP breast epithelium ENCFF955FMX 170 bp overlap

ChIP esophagus muscularis mucosa ENCFF432ZCY 166 bp overlap

ChIP esophagus muscularis mucosa ENCFF759BBR 234 bp overlap

ChIP esophagus muscularis mucosa ENCFF791ZXN 178 bp overlap

ChIP gastroesophageal sphincter ENCFF070PCA 131 bp overlap

ChIP neural cell ENCFF604SPB 378 bp overlap

ChIP prostate gland ENCFF881OMH 340 bp overlap

ChIP prostate gland ENCFF881OMH 86 bp overlap

ChIP sigmoid colon ENCFF725QFT 170 bp overlap

ChIP sigmoid colon ENCFF748YVT 179 bp overlap

ChIP sigmoid colon ENCFF754JQR 122 bp overlap

ChIP sigmoid colon ENCFF754JQR 320 bp overlap

ChIP spleen ENCFF044PYR 170 bp overlap

ChIP spleen ENCFF446ZGT 209 bp overlap

ChIP spleen ENCFF706IUS 378 bp overlap

ChIP stomach ENCFF607ZPU 227 bp overlap

ChIP transverse colon ENCFF607LKE 151 bp overlap

ChIP transverse colon ENCFF610RWV 156 bp overlap

ChIP transverse colon ENCFF840PXT 210 bp overlap

ChIP upper lobe of left lung ENCFF640VPA 338 bp overlap

ChIP vagina ENCFF384GAB 378 bp overlap

POU2F1 1 dataset

ChIP T-47D_D538G GSE148277.POU2F1.T-47D_D538G 311 bp overlap

POU5F1 5 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 342 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 378 bp overlap

ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 230 bp overlap

ChIP SKM-1 GSE93706.POU5F1.SKM-1 261 bp overlap

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 295 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 378 bp overlap

PTBP1 1 dataset

ChIP Hep-G2 ENCSR156APP.PTBP1.Hep-G2 194 bp overlap

RAD21 5 datasets

ChIP HCT-116 GSE131606.RAD21.HCT-116 291 bp overlap

ChIP HUVEC-C_hypoxia GSE94872.RAD21.HUVEC-C_hypoxia 168 bp overlap

ChIP HUVEC-C_normoxia GSE94872.RAD21.HUVEC-C_normoxia 122 bp overlap

ChIP neural ENCSR198ZYJ.RAD21.neural 210 bp overlap

ChIP neural cell ENCFF564MOT 130 bp overlap

RBBP5 2 datasets

ChIP WA01 ENCSR000AQC.RBBP5.WA01 194 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 75 bp overlap

RELA 2 datasets

ChIP HEK293_TNF-1h GSE75562.RELA.HEK293_TNF-1h 200 bp overlap

ChIP HUVEC-C_TNF GSE43070.RELA.HUVEC-C_TNF 129 bp overlap

RNF2 10 datasets

ChIP GM12878 ENCSR679FAB.RNF2.GM12878 335 bp overlap

ChIP H1 ENCFF239FFS 378 bp overlap

ChIP HUES-64 GSE104059.RNF2.HUES-64 171 bp overlap

ChIP Hep-G2 ENCSR523XCR.RNF2.Hep-G2 378 bp overlap

ChIP HepG2 ENCFF737WCD 178 bp overlap

ChIP HepG2 ENCFF737WCD 301 bp overlap

ChIP NCCIT GSE71675.RNF2.NCCIT 339 bp overlap

ChIP SYO-1_shCt GSE139053.RNF2.SYO-1_shCt 239 bp overlap

ChIP SYO-1_shRING1A-B GSE139053.RNF2.SYO-1_shRING1A-B 55 bp overlap

ChIP fibroblast GSE139053.RNF2.fibroblast 378 bp overlap

RORC 2 datasets

ChIP HCC70 GSE126380.RORC.HCC70 305 bp overlap

ChIP HCC70_XY018 GSE126380.RORC.HCC70_XY018 327 bp overlap

RUNX1 1 dataset

ChIP Jurkat GSE85524.RUNX1.Jurkat 198 bp overlap

SIRT6 1 dataset

ChIP SK-MEL-239_L-C-B GSE102813.SIRT6.SK-MEL-239_L-C-B 73 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 158 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 59 bp overlap

SMARCB1 1 dataset

ChIP HeLa-S3 ENCSR000EDK.SMARCB1.HeLa-S3 98 bp overlap

SMARCC1 2 datasets

ChIP Aska-SS_shSSX GSE108025.SMARCC1.Aska-SS_shSSX 378 bp overlap

ChIP ESC S25-ESC-d0-BAF155-exp1 378 bp overlap

SMC1 2 datasets

ChIP DKO GSE131606.SMC1.DKO 378 bp overlap

ChIP HCAEC GSE101921.SMC1.HCAEC 378 bp overlap

ChIP neural ENCSR404BPV.SMC3.neural 378 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 167 bp overlap

SREBP2 2 datasets

ChIP HCC70 GSE126380.SREBP2.HCC70 378 bp overlap

ChIP HCC70_XY018 GSE126380.SREBP2.HCC70_XY018 297 bp overlap

ChIP SYO-1_shRING1A-B GSE139053.SS18.SYO-1_shRING1A-B 148 bp overlap

SS18-SSX 1 dataset

ChIP fibroblast_78aa-SSX-Tail GSE139053.SS18-SSX.fibroblast_78aa-SSX-Tail 264 bp overlap

STAT1_pS727 1 dataset

ChIP SET-2 GSE100566.STAT1_pS727.SET-2 279 bp overlap

STAT3 1 dataset

ChIP MDA-MB-453 GSE152203.STAT3.MDA-MB-453 226 bp overlap

SUZ12 8 datasets

ChIP CRL-7250_shSS18-SSX GSE108025.SUZ12.CRL-7250_shSS18-SSX 290 bp overlap

ChIP GM12878 ENCSR091BOQ.SUZ12.GM12878 115 bp overlap

ChIP H1 ENCFF507HGF 265 bp overlap

ChIP H1 ENCFF881NFR 378 bp overlap

ChIP HEK293T_PCGF135fl GSE119618.SUZ12.HEK293T_PCGF135fl 52 bp overlap

ChIP NT2-D1 GSE101538.SUZ12.NT2-D1 378 bp overlap

ChIP NT2/D1 ENCFF574SXS 200 bp overlap

ChIP NT2/D1 ENCFF574SXS 259 bp overlap

ChIP ME-1 GSE46044.TAL1.ME-1 232 bp overlap

TCF7L2 2 datasets

ChIP CD34_PROG_BIO GSE29194.TCF7L2.CD34_PROG_BIO 325 bp overlap

ChIP MDA-MB-453 GSE45201.TCF7L2.MDA-MB-453 104 bp overlap

TEAD4 1 dataset

ChIP ESC S26-ESC-d0-TEAD4-exp1 344 bp overlap

TP63 2 datasets

ChIP breast-organoid GSE113909.TP63.breast-organoid 172 bp overlap

ChIP keratinocyte GSE33571.TP63.keratinocyte 190 bp overlap

TRIM25 1 dataset

ChIP BT-549 GSE79588.TRIM25.BT-549 225 bp overlap

TRIM28 1 dataset

ChIP AF22 GSE84259.TRIM28.AF22 307 bp overlap

ChIP SMMC-7721 GSE126982.WDR5.SMMC-7721 308 bp overlap

ZBTB21 1 dataset

ChIP WTC11 ENCFF677ZYY 378 bp overlap

ZBTB48 1 dataset

ChIP U2OS_ZBTB48-KO GSE96776.ZBTB48.U2OS_ZBTB48-KO 377 bp overlap

ZFP36 2 datasets

ChIP Hep-G2 ENCSR382XLA.ZFP36.Hep-G2 240 bp overlap

ChIP HepG2 ENCFF486SQU 191 bp overlap

ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 298 bp overlap

ZNF263 1 dataset

ChIP K-562 ENCSR000EWN.ZNF263.K-562 262 bp overlap

ZNF479 1 dataset

ChIP HEK293T GSE78099.ZNF479.HEK293T 264 bp overlap