Transcription factors with Perturb-seq knockdown data for ENSG00000259725. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259725 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259725, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:54,927,769–54,931,725 | 6.9 kb | Proximal (<10kb) | 746 | |
| chr16:54,931,969–54,933,833 | 4.8 kb | Proximal (<10kb) | 172 | |
| chr16:54,934,833–54,935,237 | 3.4 kb | Proximal (<10kb) | 113 | |
| chr16:54,936,252–54,937,937 | 733 bp | At TSS | 276 | |
| chr16:54,938,325–54,938,703 | at TSS | At TSS | 99 | |
| chr16:54,938,813–54,939,012 | 142 bp | At TSS | 60 |
Genomic view of the ENSG00000259725 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.